PMID- 24289908 OWN - NLM STAT- MEDLINE DCOM- 20141017 LR - 20221207 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 215 IP - 1 DP - 2014 Jan 30 TI - Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and aggressive behavior in schizophrenia. PG - 244-5 LID - S0165-1781(13)00665-3 [pii] LID - 10.1016/j.psychres.2013.10.017 [doi] AB - We investigated the association of the Val66Met gene polymorphism in the Brain-Derived Neurotrophic Factor (BDNF) gene with aggressive behavior among Southern Han Chinese schizophrenia patients. We used polymerase chain reaction-restriction fragment length polymorphism to determine the genotypes and the Modified Overt Aggression Scale (MOAS) to measure aggressive behavior. No significant differences in genotype or allele distribution of Val66Met were identified between aggressive and non-aggressive schizophrenia patients. CI - (c) 2013 Published by Elsevier Ireland Ltd. FAU - Guan, Xuan AU - Guan X AD - School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan, China. FAU - Dong, Zai-Quan AU - Dong ZQ AD - Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Tian, Yuan-Yuan AU - Tian YY AD - Department of Anesthesia and Intensive Care, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong. FAU - Wu, Li-Na AU - Wu LN AD - School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan, China. FAU - Gu, Yan AU - Gu Y AD - Department of Forensic Psychiatry, Sichuan University, Chengdu, Sichuan, China. FAU - Hu, Ze-Qing AU - Hu ZQ AD - Department of Forensic Psychiatry, Sichuan University, Chengdu, Sichuan, China. Electronic address: hezeqing@126.com. FAU - Zhang, Xiao AU - Zhang X AD - School of Basic Medical Sciences, Chengdu Medical College, Chengdu, Sichuan, China. Electronic address: medical8989@126.com. LA - eng PT - Journal Article DEP - 20131107 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adolescent MH - Adult MH - Aggression/*physiology/psychology MH - Alleles MH - Asian People/genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - Female MH - Genotype MH - Humans MH - Male MH - Middle Aged MH - *Polymorphism, Single Nucleotide MH - Schizophrenia/*genetics MH - *Schizophrenic Psychology MH - Young Adult OTO - NOTNLM OT - Aggression OT - Genetic association OT - Modified Overt Aggression Scale (MOAS) EDAT- 2013/12/03 06:00 MHDA- 2014/10/18 06:00 CRDT- 2013/12/03 06:00 PHST- 2012/11/03 00:00 [received] PHST- 2013/09/08 00:00 [revised] PHST- 2013/10/16 00:00 [accepted] PHST- 2013/12/03 06:00 [entrez] PHST- 2013/12/03 06:00 [pubmed] PHST- 2014/10/18 06:00 [medline] AID - S0165-1781(13)00665-3 [pii] AID - 10.1016/j.psychres.2013.10.017 [doi] PST - ppublish SO - Psychiatry Res. 2014 Jan 30;215(1):244-5. doi: 10.1016/j.psychres.2013.10.017. Epub 2013 Nov 7.