PMID- 24290367 OWN - NLM STAT- MEDLINE DCOM- 20140829 LR - 20211021 IS - 1879-1379 (Electronic) IS - 0022-3956 (Print) IS - 0022-3956 (Linking) VI - 49 DP - 2014 Feb TI - Brain-derived neurotrophic factor levels in late-life depression and comorbid mild cognitive impairment: a longitudinal study. PG - 96-101 LID - S0022-3956(13)00343-9 [pii] LID - 10.1016/j.jpsychires.2013.11.004 [doi] AB - Changes in brain-derived neurotrophic factor (BDNF) level are implicated in the pathophysiology of cognitive decline in depression and neurodegenerative disorders in older adults. We aimed to evaluate the longitudinal association over two years between BDNF and persistent cognitive decline in individuals with remitted late-life depression and Mild Cognitive Impairment (LLD + MCI) compared to either individuals with remitted LLD and no cognitive decline (LLD + NCD) or never-depressed, cognitively normal, elderly control participants. We additionally evaluated the effect of double-blind, placebo-controlled donepezil treatment on BDNF levels in all of the remitted LLD participants (across the levels of cognitive function). We included 160 elderly participants in this study (72 LLD + NCD, 55 LLD + MCI and 33 never-depressed cognitively normal elderly participants). At the same visits, cognitive assessments were conducted and blood sampling to determine serum BDNF levels were collected at baseline assessment and after one and two years of follow-up. We utilized repeated measure, mixed effect models to assess: (1) the effects of diagnosis (LLD + MCI, LLD + NCD, and controls), time, and their interaction on BDNF levels; and (2) the effects of donepezil treatment (donepezil vs. placebo), time, baseline diagnosis (LLD + MCI vs. LLD + NCD), and interactions between these contrasts on BDNF levels. We found a significant effect of time on BDNF level (p = 0.02) and a significant decline in BDNF levels over 2 years of follow-up in participants with LLD + MCI (p = 0.004) and controls (p = 0.04). We found no effect of donepezil treatment on BDNF level. The present results suggest that aging is an important factor related to decline in BDNF level. Clinicaltrials.gov Identifier: NCT00177671. CI - Copyright (c) 2013 Elsevier Ltd. All rights reserved. FAU - Diniz, Breno Satler AU - Diniz BS AD - Department of Mental Health, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: brenosatler@gmail.com. FAU - Reynolds, Charles F 3rd AU - Reynolds CF 3rd AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Begley, Amy AU - Begley A AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Dew, Mary Amanda AU - Dew MA AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Anderson, Stewart J AU - Anderson SJ AD - Department of Biostatistics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA. FAU - Lotrich, Francis AU - Lotrich F AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Erickson, Kirk I AU - Erickson KI AD - Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA; Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA, USA. FAU - Lopez, Oscar AU - Lopez O AD - Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA. FAU - Aizenstein, Howard AU - Aizenstein H AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Sibille, Etienne L AU - Sibille EL AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Butters, Meryl A AU - Butters MA AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. LA - eng SI - ClinicalTrials.gov/NCT00177671 GR - P50AG05133/AG/NIA NIH HHS/United States GR - UL1 TR000005/TR/NCATS NIH HHS/United States GR - UL1 RR024153/RR/NCRR NIH HHS/United States GR - R01 MH043823/MH/NIMH NIH HHS/United States GR - R01MH080240/MH/NIMH NIH HHS/United States GR - P30 MH071944/MH/NIMH NIH HHS/United States GR - R01MH072947/MH/NIMH NIH HHS/United States GR - P50 AG005133/AG/NIA NIH HHS/United States GR - R01 MH072947/MH/NIMH NIH HHS/United States GR - R01 MH037869/MH/NIMH NIH HHS/United States GR - P30MH071944/MH/NIMH NIH HHS/United States GR - P30 MH090333/MH/NIMH NIH HHS/United States GR - R01 MH080240/MH/NIMH NIH HHS/United States GR - UL1TR000005/TR/NCATS NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20131120 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 RN - 0 (Antidepressive Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Indans) RN - 0 (Piperidines) RN - 8SSC91326P (Donepezil) SB - IM MH - Aged MH - Aged, 80 and over MH - Antidepressive Agents/therapeutic use MH - Brain-Derived Neurotrophic Factor/*blood MH - Cognitive Dysfunction/*blood/drug therapy/*epidemiology MH - Depression/drug therapy/*epidemiology MH - Donepezil MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - Humans MH - Indans/therapeutic use MH - Linear Models MH - Longitudinal Studies MH - Male MH - Piperidines/therapeutic use MH - Time Factors PMC - PMC3921964 MID - NIHMS542571 OTO - NOTNLM OT - BDNF OT - Dementia OT - Elderly OT - Late-life depression OT - Mild cognitive impairment, OT - Pathophysiology EDAT- 2013/12/03 06:00 MHDA- 2014/08/30 06:00 PMCR- 2015/02/01 CRDT- 2013/12/03 06:00 PHST- 2013/07/02 00:00 [received] PHST- 2013/10/30 00:00 [revised] PHST- 2013/11/11 00:00 [accepted] PHST- 2013/12/03 06:00 [entrez] PHST- 2013/12/03 06:00 [pubmed] PHST- 2014/08/30 06:00 [medline] PHST- 2015/02/01 00:00 [pmc-release] AID - S0022-3956(13)00343-9 [pii] AID - 10.1016/j.jpsychires.2013.11.004 [doi] PST - ppublish SO - J Psychiatr Res. 2014 Feb;49:96-101. doi: 10.1016/j.jpsychires.2013.11.004. Epub 2013 Nov 20.