PMID- 24291483 OWN - NLM STAT- MEDLINE DCOM- 20141208 LR - 20180816 IS - 1532-2653 (Electronic) IS - 0967-5868 (Linking) VI - 21 IP - 5 DP - 2014 May TI - The role of the brain-derived neurotrophic factor SNP rs2883187 in the phenotypic expression of obsessive-compulsive disorder. PG - 790-3 LID - S0967-5868(13)00533-X [pii] LID - 10.1016/j.jocn.2013.07.037 [doi] AB - We investigated the association between a brain-derived neurotrophic factor (BDNF) gene polymorphism and clinical features in a sample of patients with obsessive-compulsive disorder (OCD). A total of 100 patients diagnosed with OCD according to the Diagnostic and Statistical Manual IV criteria and 110 control subjects were included in this study. The distribution of a single nucleotide polymorphism rs2883187 was compared in OCD patients and normal controls. Clinical features were compared between the subgroups of OCD patients with different genotypes. There was no significant difference for the allele frequencies and genotype distributions between the OCD and control groups. The Hamilton Anxiety Rating Scale, Yale-Brown Obsessive Compulsive Scale obsession and total scores were found to be higher in patients with the CC genotype than in the patients who are homozygous for the T allele. The rates of OCD in first-degree relatives of OCD patients who were homozygous for the C allele were significantly higher, compared to those with CT and TT genotypes. Our results indicate that the CC genotype may be associated with the severity and increased familial loading of OCD. Further investigation based on larger populations is needed to reveal the full association of the BDNF polymorphism with OCD. CI - Copyright (c) 2013 Elsevier Ltd. All rights reserved. FAU - Tukel, Rasit AU - Tukel R AD - Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey. Electronic address: rtukel@gmail.com. FAU - Ozata, Berna AU - Ozata B AD - Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey. FAU - Ozturk, Nalan AU - Ozturk N AD - Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey. FAU - Ertekin, Banu Aslantas AU - Ertekin BA AD - Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey. FAU - Ertekin, Erhan AU - Ertekin E AD - Istanbul University, Istanbul Faculty of Medicine, Department of Psychiatry, Istanbul, Turkey. FAU - Direskeneli, Guher Saruhan AU - Direskeneli GS AD - Istanbul University, Istanbul Faculty of Medicine, Department of Physiology, Istanbul, Turkey. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20131011 PL - Scotland TA - J Clin Neurosci JT - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JID - 9433352 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Brain-Derived Neurotrophic Factor/*genetics MH - Female MH - *Gene Expression Regulation MH - Humans MH - Male MH - Obsessive-Compulsive Disorder/*diagnosis/*genetics/psychology MH - *Phenotype MH - Polymorphism, Single Nucleotide/*genetics MH - Young Adult OTO - NOTNLM OT - BDNF OT - Obsessive-compulsive disorder OT - SNP OT - rs2883187 EDAT- 2013/12/03 06:00 MHDA- 2014/12/15 06:00 CRDT- 2013/12/03 06:00 PHST- 2013/01/24 00:00 [received] PHST- 2013/07/16 00:00 [accepted] PHST- 2013/12/03 06:00 [entrez] PHST- 2013/12/03 06:00 [pubmed] PHST- 2014/12/15 06:00 [medline] AID - S0967-5868(13)00533-X [pii] AID - 10.1016/j.jocn.2013.07.037 [doi] PST - ppublish SO - J Clin Neurosci. 2014 May;21(5):790-3. doi: 10.1016/j.jocn.2013.07.037. Epub 2013 Oct 11.