PMID- 24291771
OWN - NLM
STAT- MEDLINE
DCOM- 20150213
LR  - 20140414
IS  - 1873-7544 (Electronic)
IS  - 0306-4522 (Linking)
VI  - 266
DP  - 2014 Apr 25
TI  - Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against 
      traumatic brain injury in mice.
PG  - 235-43
LID - S0306-4522(13)00983-4 [pii]
LID - 10.1016/j.neuroscience.2013.11.036 [doi]
AB  - The aim of present study was to elucidate the role of Interleukin-10 (IL-10) in 
      the neuroprotection of hyperbaric oxygen (HBO) against traumatic brain injury 
      (TBI) in mice. The TBI in mice was induced by controlled cortical impact (CCI). 
      HBO was given for 1h at 2.0 absolute atmosphere (ATA) in 100% O2. HBO enhanced 
      the serumal and cerebral IL-10 protein levels in both sham-operated and TBI mice. 
      HBO therapy after TBI reduced lesion volume, attenuated cerebral edema, improved 
      neurological status including motor and cognitive function, inhibited apoptosis 
      evidenced by decreased ratio of cleaved caspase-3 (C3) to pro-C3 and Bax 
      expression and increased bcl-2 expression, and attenuated inflammation marked by 
      reduced expression of IL-1beta, IL-6, macrophage inflammatory protein-2 (MIP-2), and 
      monocyte chemoattractant protein-1 (MCP-1) and activity of matrix 
      metalloproteinase-9 (MMP9). In addition, HBO after TBI improved the blood-brain 
      barrier, and upregulated the expression of tight junction proteins including 
      zonula occludens-1 (ZO-1) and claudin-5. IL-10 deficiency aggravated TBI-induced 
      damage in the brain and abrogated the beneficial effects of HBO on 
      neuroinflammation, apoptosis, and edema after TBI. IL-10 deficiency itself had no 
      significant effect on brain water content and neurological status. In conclusion, 
      IL-10 played an important role in the neuroprotection of HBO therapy against TBI 
      in mice.
CI  - Copyright (c) 2014. Published by Elsevier Ltd.
FAU - Chen, X
AU  - Chen X
AD  - Department of Hyperbaric Oxygen, The 113th Hospital of PLA, Ningbo, Zhejiang, 
      China.
FAU - Duan, X-S
AU  - Duan XS
AD  - Department of Hyperbaric Oxygen, The 113th Hospital of PLA, Ningbo, Zhejiang, 
      China.
FAU - Xu, L-J
AU  - Xu LJ
AD  - Department of Hyperbaric Oxygen, The 113th Hospital of PLA, Ningbo, Zhejiang, 
      China.
FAU - Zhao, J-J
AU  - Zhao JJ
AD  - Department of Neurology, The 305th Hospital of PLA, Beijing, China.
FAU - She, Z-F
AU  - She ZF
AD  - Department of Hyperbaric Oxygen, The 113th Hospital of PLA, Ningbo, Zhejiang, 
      China.
FAU - Chen, W-W
AU  - Chen WW
AD  - Department of Hyperbaric Oxygen, The 113th Hospital of PLA, Ningbo, Zhejiang, 
      China.
FAU - Zheng, Z-J
AU  - Zheng ZJ
AD  - Department of Hyperbaric Oxygen, The 113th Hospital of PLA, Ningbo, Zhejiang, 
      China.
FAU - Jiang, G-D
AU  - Jiang GD
AD  - Department of Hyperbaric Oxygen, The 113th Hospital of PLA, Ningbo, Zhejiang, 
      China. Electronic address: jianggd2013@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20131127
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (IL10 protein, mouse)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Animals
MH  - Apoptosis/physiology
MH  - Blood-Brain Barrier/pathology
MH  - Blotting, Western
MH  - Brain Injuries/*metabolism/*pathology
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - *Hyperbaric Oxygenation
MH  - Immunohistochemistry
MH  - Interleukin-10/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
OTO - NOTNLM
OT  - apoptosis
OT  - edema
OT  - hyperbaric oxygen
OT  - inflammation
OT  - interleukin-10
OT  - traumatic brain injury
EDAT- 2013/12/03 06:00
MHDA- 2015/02/14 06:00
CRDT- 2013/12/03 06:00
PHST- 2013/09/14 00:00 [received]
PHST- 2013/11/20 00:00 [revised]
PHST- 2013/11/20 00:00 [accepted]
PHST- 2013/12/03 06:00 [entrez]
PHST- 2013/12/03 06:00 [pubmed]
PHST- 2015/02/14 06:00 [medline]
AID - S0306-4522(13)00983-4 [pii]
AID - 10.1016/j.neuroscience.2013.11.036 [doi]
PST - ppublish
SO  - Neuroscience. 2014 Apr 25;266:235-43. doi: 10.1016/j.neuroscience.2013.11.036. 
      Epub 2013 Nov 27.