PMID- 24292056
OWN - NLM
STAT- MEDLINE
DCOM- 20140714
LR  - 20190720
IS  - 1347-5215 (Electronic)
IS  - 0918-6158 (Linking)
VI  - 36
IP  - 12
DP  - 2013
TI  - Supplementary seleno-L-methionine suppresses active cutaneous anaphylaxis 
      reaction.
PG  - 1969-74
AB  - To clarify the relationship between selenium supplementation and type I allergic 
      reaction, we investigated the effect of seleno-L-methionine (SeMet) 
      supplementation on the active cutaneous anaphylaxis (ACA) reaction and cytokine 
      production in splenocytes. Female BALB/c mice were sensitized by intraperitoneal 
      injection of ovalbumin (OVA), and SeMet was administered orally for 2 weeks 
      followed by a challenge with OVA to induce an ACA reaction. SeMet supplementation 
      suppressed the ACA reaction in a dose-dependent manner. Plasma OVA-specific 
      immunoglobulin E (IgE) level was strongly inhibited in SeMet-supplemented mice 
      compared with control mice. The mRNA expression levels of the T helper 2 (Th2) 
      cytokines interleukin (IL)-4 and IL-13 in the spleen of SeMet-supplemented mice 
      were lower than those in control mice. The mRNA expression level of a Th1 
      cytokine, interferon (IFN)-gamma, in the spleen of SeMet-supplemented mice was higher 
      than that in control mice. Splenocytes restimulated with OVA in vitro from 
      SeMet-supplemented mice produced lower amounts of IL-4 and IL-13 than those of 
      control mice and higher amounts of IFN-gamma than those from the control mice. These 
      results suggest that oral SeMet supplementation suppresses OVA-induced ACA 
      reaction by lowered Th2 cytokine production and augmenting Th1 cytokine 
      production.
FAU - Arakawa, Tomohiro
AU  - Arakawa T
AD  - Department of Public Health & Preventive Pharmacology, Faculty of Pharmaceutical 
      Sciences, Setsunan University.
FAU - Deguchi, Takeshi
AU  - Deguchi T
FAU - Sakazaki, Fumitoshi
AU  - Sakazaki F
FAU - Ogino, Hirofumi
AU  - Ogino H
FAU - Okuno, Tomofumi
AU  - Okuno T
FAU - Ueno, Hitoshi
AU  - Ueno H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Cytokines)
RN  - 0 (RNA, Messenger)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9006-59-1 (Ovalbumin)
RN  - 964MRK2PEL (Selenomethionine)
SB  - IM
MH  - Anaphylaxis/*drug therapy/metabolism
MH  - Animals
MH  - Cytokines/genetics/metabolism
MH  - Disease Models, Animal
MH  - Female
MH  - Hypersensitivity/*drug therapy/metabolism
MH  - Immunoglobulin E/blood
MH  - Liver/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
MH  - RNA, Messenger/metabolism
MH  - Selenomethionine/blood/pharmacokinetics/*therapeutic use
MH  - Skin Tests
MH  - Spleen/cytology/metabolism
EDAT- 2013/12/03 06:00
MHDA- 2014/07/16 06:00
CRDT- 2013/12/03 06:00
PHST- 2013/12/03 06:00 [entrez]
PHST- 2013/12/03 06:00 [pubmed]
PHST- 2014/07/16 06:00 [medline]
AID - DN/JST.JSTAGE/bpb/b13-00598 [pii]
AID - 10.1248/bpb.b13-00598 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2013;36(12):1969-74. doi: 10.1248/bpb.b13-00598.