PMID- 24292089
OWN - NLM
STAT- MEDLINE
DCOM- 20140130
LR  - 20131202
IS  - 1217-8950 (Print)
IS  - 1217-8950 (Linking)
VI  - 60
IP  - 4
DP  - 2013 Dec
TI  - In vitro efficiency of vancomycin containing experimental drug delivery systems.
PG  - 461-8
LID - 10.1556/AMicr.60.2013.4.7 [doi]
AB  - Biofilm-forming Staphylococcus epidermidis strains are common cause of the 
      periprosthetic infection. The treatment of the periprosthetic infection is very 
      problematic, so the prevention of these infections by an antibiotic containing 
      prothesis could be an option for prevention.The purpose of the present study was 
      to examine the in vitro effects of drug delivery systems (DDSs), namely Wax 1 and 
      Wax 2 with different vancomycin content: 0.5, 1, 2 and 4 mg. In order to control 
      the antibacterial activity of DDSs killing curve study was performed and in order 
      to determine the antibiotic release and the antibiotic peak concentration from 
      the DDSs biological assay was carried out.The time kill curve studies showed, 
      that both DDSs with all vancomycin concentration decreased significantly the 
      bacterial counts, however, Wax 2 with 4 mg vancomycin significantly decreased the 
      bacterial count than all the other groups.The vancomycin release was the best 
      with the highest peak concentration from DDSs with 4 mg vancomycin contain; it 
      was significantly better than in the other groups, however, no significant 
      difference was observed between Wax 1 and Wax 2 in this respect.These findings 
      suggest that Wax 2 with 4 mg vancomycin content could be a potential agent for 
      clinical use.
FAU - Szasz, Mate
AU  - Szasz M
AD  - Semmelweis University Institute of Medical Microbiology Budapest Hungary.
FAU - Hajdu, Maria
AU  - Hajdu M
FAU - Pesti, Natasa
AU  - Pesti N
FAU - Domahidy, Monika
AU  - Domahidy M
FAU - Kristof, Katalin
AU  - Kristof K
FAU - Zahar, Akos
AU  - Zahar A
FAU - Nagy, Karoly
AU  - Nagy K
FAU - Szabo, Dora
AU  - Szabo D
LA  - eng
PT  - Journal Article
PL  - Hungary
TA  - Acta Microbiol Immunol Hung
JT  - Acta microbiologica et immunologica Hungarica
JID - 9434021
RN  - 0 (Anti-Bacterial Agents)
RN  - 6Q205EH1VU (Vancomycin)
SB  - IM
MH  - Anti-Bacterial Agents/*administration & dosage
MH  - Bacterial Load
MH  - *Drug Delivery Systems
MH  - Staphylococcus epidermidis/drug effects
MH  - Vancomycin/*administration & dosage
OTO - NOTNLM
OT  - drug delivery system
OT  - vancomycin
EDAT- 2013/12/03 06:00
MHDA- 2014/01/31 06:00
CRDT- 2013/12/03 06:00
PHST- 2013/12/03 06:00 [entrez]
PHST- 2013/12/03 06:00 [pubmed]
PHST- 2014/01/31 06:00 [medline]
AID - 6570M5706H7PX657 [pii]
AID - 10.1556/AMicr.60.2013.4.7 [doi]
PST - ppublish
SO  - Acta Microbiol Immunol Hung. 2013 Dec;60(4):461-8. doi: 
      10.1556/AMicr.60.2013.4.7.