PMID- 24292283
OWN - NLM
STAT- MEDLINE
DCOM- 20141024
LR  - 20211021
IS  - 1435-165X (Electronic)
IS  - 1018-8827 (Linking)
VI  - 23
IP  - 8
DP  - 2014 Aug
TI  - BDNF genetic variability modulates psychopathological symptoms in patients with 
      eating disorders.
PG  - 669-79
LID - 10.1007/s00787-013-0495-6 [doi]
AB  - The brain-derived neurotrophic factor (BDNF) gene may influence eating behavior, 
      body weight and cognitive impairments. We aimed to investigate whether BDNF 
      genetic variability may affect anthropometric and psychological parameters in 
      patients with anorexia or bulimia nervosa (AN, BN) and/or modulate the risk for 
      the disorder. A total of 169 unrelated female patients and 312 healthy controls 
      were genotyped for two common BDNF single-nucleotide polymorphisms (SNPs), 
      Val66Met and C-270T, and several selected tag-SNPs. Associated personality 
      characteristics and psychopathological symptoms were assessed by the EDI-2 and 
      SCL-90R inventories, respectively. No single SNP or haplotype played a relevant 
      role in the risk for AN or BN. The rs16917237 TT genotype was significantly 
      associated with increased weight (74.63 +/- 16.58 vs. 57.93 +/- 13.02) and body mass 
      index (28.94 +/- 6.22 vs. 22.23 +/- 4.77) in the BN group after correcting for 
      multiple testing. Haplotype analyses using a sliding window approach with three 
      adjacent SNPs produced four loci of interest. Locus 3 
      (rs10835210/rs16917237/C-270T) showed a broad impact on the measured 
      psychopathological symptoms. Haplotypes CGC and CGT in this locus correlated with 
      scores in all three scales of the SCL-90R inventory, both in AN and BN patients. 
      In contrast, the results of the EDI-2 inventory were largely unaffected. These 
      preliminary results suggest that variability in the BDNF gene locus may 
      contribute to anthropometric characteristics and also psychopathological symptoms 
      that are common but not exclusive of ED patients.
FAU - Gamero-Villarroel, Carmen
AU  - Gamero-Villarroel C
AD  - Division of Clinical Pharmacology, Department of Medical and Surgical 
      Therapeutics, Medical School, University of Extremadura, Avda. de Elvas s/n, 
      06005, Badajoz, Spain.
FAU - Gordillo, Inmaculada
AU  - Gordillo I
FAU - Carrillo, Juan Antonio
AU  - Carrillo JA
FAU - Garcia-Herraiz, Angustias
AU  - Garcia-Herraiz A
FAU - Flores, Isalud
AU  - Flores I
FAU - Jimenez, Mercedes
AU  - Jimenez M
FAU - Monge, Melchora
AU  - Monge M
FAU - Rodriguez-Lopez, Raquel
AU  - Rodriguez-Lopez R
FAU - Gervasini, Guillermo
AU  - Gervasini G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131129
PL  - Germany
TA  - Eur Child Adolesc Psychiatry
JT  - European child & adolescent psychiatry
JID - 9212296
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Anorexia Nervosa/*genetics/*psychology
MH  - Body Mass Index
MH  - Body Weight/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Bulimia Nervosa/*genetics/*psychology
MH  - Case-Control Studies
MH  - Cognition Disorders/genetics
MH  - Feeding Behavior/psychology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Polymorphism, Single Nucleotide
MH  - Psychopathology
EDAT- 2013/12/03 06:00
MHDA- 2014/10/25 06:00
CRDT- 2013/12/03 06:00
PHST- 2013/07/29 00:00 [received]
PHST- 2013/11/09 00:00 [accepted]
PHST- 2013/12/03 06:00 [entrez]
PHST- 2013/12/03 06:00 [pubmed]
PHST- 2014/10/25 06:00 [medline]
AID - 10.1007/s00787-013-0495-6 [doi]
PST - ppublish
SO  - Eur Child Adolesc Psychiatry. 2014 Aug;23(8):669-79. doi: 
      10.1007/s00787-013-0495-6. Epub 2013 Nov 29.