PMID- 24292363
OWN - NLM
STAT- MEDLINE
DCOM- 20140226
LR  - 20240213
IS  - 1529-2916 (Electronic)
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 15
IP  - 1
DP  - 2014 Jan
TI  - Comparative transcriptional and functional profiling defines conserved programs 
      of intestinal DC differentiation in humans and mice.
PG  - 98-108
LID - 10.1038/ni.2768 [doi]
AB  - Dendritic cells (DCs) that orchestrate mucosal immunity have been studied in 
      mice. Here we characterized human gut DC populations and defined their 
      relationship to previously studied human and mouse DCs. CD103(+)Sirpalpha(-) DCs were 
      related to human blood CD141(+) DCs and to mouse intestinal CD103(+)CD11b(-) DCs 
      and expressed markers of cross-presenting DCs. CD103(+)Sirpalpha(+) DCs aligned with 
      human blood CD1c(+) DCs and mouse intestinal CD103(+)CD11b(+) DCs and supported 
      the induction of regulatory T cells. Both CD103(+) DC subsets induced the TH17 
      subset of helper T cells, while CD103(-)Sirpalpha(+) DCs induced the TH1 subset of 
      helper T cells. Comparative analysis of transcriptomes revealed conserved 
      transcriptional programs among CD103(+) DC subsets and identified a selective 
      role for the transcriptional repressors Bcl-6 and Blimp-1 in the specification of 
      CD103(+)CD11b(-) DCs and intestinal CD103(+)CD11b(+) DCs, respectively. Our 
      results highlight evolutionarily conserved and divergent programming of 
      intestinal DCs.
FAU - Watchmaker, Payal B
AU  - Watchmaker PB
AD  - 1] Laboratory of Immunology and Vascular Biology, Department of Pathology, 
      Stanford University School of Medicine, Stanford, California, USA. [2] The Center 
      for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care 
      System, Palo Alto, California, USA. [3].
FAU - Lahl, Katharina
AU  - Lahl K
AD  - 1] Laboratory of Immunology and Vascular Biology, Department of Pathology, 
      Stanford University School of Medicine, Stanford, California, USA. [2] The Center 
      for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care 
      System, Palo Alto, California, USA. [3].
FAU - Lee, Mike
AU  - Lee M
AD  - 1] Laboratory of Immunology and Vascular Biology, Department of Pathology, 
      Stanford University School of Medicine, Stanford, California, USA. [2] The Center 
      for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care 
      System, Palo Alto, California, USA.
FAU - Baumjohann, Dirk
AU  - Baumjohann D
AD  - Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, 
      University of California San Francisco, San Francisco, California, USA.
FAU - Morton, John
AU  - Morton J
AD  - Department of Surgery, Stanford University School of Medicine, Stanford, 
      California, USA.
FAU - Kim, Sun Jung
AU  - Kim SJ
AD  - Center for Autoimmune and Musculoskeletal Diseases, the Feinstein Institute for 
      Medical Research, Manhasset, New York, USA.
FAU - Zeng, Ruizhu
AU  - Zeng R
AD  - 1] Laboratory of Immunology and Vascular Biology, Department of Pathology, 
      Stanford University School of Medicine, Stanford, California, USA. [2] The Center 
      for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care 
      System, Palo Alto, California, USA.
FAU - Dent, Alexander
AU  - Dent A
AD  - Department of Microbiology and Immunology, Indiana University School of Medicine, 
      Indianapolis, Indiana, USA.
FAU - Ansel, K Mark
AU  - Ansel KM
AD  - Department of Microbiology and Immunology, Sandler Asthma Basic Research Center, 
      University of California San Francisco, San Francisco, California, USA.
FAU - Diamond, Betty
AU  - Diamond B
AD  - Center for Autoimmune and Musculoskeletal Diseases, the Feinstein Institute for 
      Medical Research, Manhasset, New York, USA.
FAU - Hadeiba, Husein
AU  - Hadeiba H
AD  - 1] The Center for Molecular Biology and Medicine, Veterans Affairs Palo Alto 
      Health Care System, Palo Alto, California, USA. [2] Palo Alto Institute for 
      Research & Education, Palo Alto, California, USA.
FAU - Butcher, Eugene C
AU  - Butcher EC
AD  - 1] Laboratory of Immunology and Vascular Biology, Department of Pathology, 
      Stanford University School of Medicine, Stanford, California, USA. [2] The Center 
      for Molecular Biology and Medicine, Veterans Affairs Palo Alto Health Care 
      System, Palo Alto, California, USA. [3] Palo Alto Institute for Research & 
      Education, Palo Alto, California, USA.
LA  - eng
SI  - GEO/GSE50380
GR  - T32 AI007290/AI/NIAID NIH HHS/United States
GR  - AI07290/AI/NIAID NIH HHS/United States
GR  - 5T32AI007290-25/AI/NIAID NIH HHS/United States
GR  - K01 AR059378/AR/NIAMS NIH HHS/United States
GR  - AI007290/AI/NIAID NIH HHS/United States
GR  - P30 DK056339/DK/NIDDK NIH HHS/United States
GR  - R01 DK084647/DK/NIDDK NIH HHS/United States
GR  - K01 AR59378/AR/NIAMS NIH HHS/United States
GR  - R01 AI093981/AI/NIAID NIH HHS/United States
GR  - R37 AI047822/AI/NIAID NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20131201
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (CD11b Antigen)
RN  - 0 (CD1C protein, human)
RN  - 0 (Glycoproteins)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (Integrins)
RN  - 0 (Receptors, Chemokine)
RN  - 0 (alpha E integrins)
SB  - IM
MH  - Animals
MH  - Antigens, CD/immunology/metabolism
MH  - Antigens, CD1/immunology/metabolism
MH  - CD11b Antigen/immunology/metabolism
MH  - Cell Differentiation/genetics/*immunology
MH  - Cells, Cultured
MH  - Cluster Analysis
MH  - Cross-Priming/genetics/immunology
MH  - Dendritic Cells/*immunology/metabolism
MH  - Flow Cytometry
MH  - Glycoproteins/immunology/metabolism
MH  - Humans
MH  - Integrin alpha Chains/immunology/metabolism
MH  - Integrins/genetics/immunology
MH  - Intestinal Mucosa/*immunology
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Microscopy, Confocal
MH  - Oligonucleotide Array Sequence Analysis
MH  - Receptors, Chemokine/genetics/immunology
MH  - T-Lymphocytes, Regulatory/immunology/metabolism
MH  - Th17 Cells/immunology/metabolism
MH  - Transcriptome/genetics/*immunology
PMC - PMC3942165
MID - NIHMS532987
EDAT- 2013/12/03 06:00
MHDA- 2014/02/27 06:00
PMCR- 2014/07/01
CRDT- 2013/12/03 06:00
PHST- 2013/07/15 00:00 [received]
PHST- 2013/10/18 00:00 [accepted]
PHST- 2013/12/03 06:00 [entrez]
PHST- 2013/12/03 06:00 [pubmed]
PHST- 2014/02/27 06:00 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - ni.2768 [pii]
AID - 10.1038/ni.2768 [doi]
PST - ppublish
SO  - Nat Immunol. 2014 Jan;15(1):98-108. doi: 10.1038/ni.2768. Epub 2013 Dec 1.