PMID- 24292896
OWN - NLM
STAT- MEDLINE
DCOM- 20150102
LR  - 20211021
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Print)
IS  - 1059-7700 (Linking)
VI  - 23
IP  - 3
DP  - 2014 Jun
TI  - Public trust in genomic risk assessment for type 2 diabetes mellitus.
PG  - 401-8
LID - 10.1007/s10897-013-9674-3 [doi]
AB  - Patient trust in personal medical information is critical to increasing adherence 
      to physician recommendations and medications. One of the anticipated benefits of 
      learning of one's genomic risk for common diseases is the increased adoption of 
      screening, preventive care and lifestyle changes. However, the equivocal results 
      thus far reported of the positive impact of knowledge of genomic risk on behavior 
      change may be due to lack of patients' trust in the results. As part of a 
      clinical study to compare two methods of communication of genomic risk results 
      for Type 2 diabetes mellitus (T2DM), we assessed patients' trust and preferred 
      methods of delivery of genomic risk information. A total of 300 participants 
      recruited from the general public in Durham, NC were randomized to receive their 
      genomic risk for T2DM in-person from a genetic counselor or online through the 
      testing company's web-site. Participants completed a baseline survey and three 
      follow-up surveys after receiving results. Overall, participants reported high 
      levels of trust in the test results. Participants who received their results 
      in-person from the genetic counselor were significantly more likely to trust 
      their results than those who reviewed their results on-line (p = 0.005). There 
      was not a statistically significant difference in levels of trust among 
      participants with increased genetic risk, as compared to other those with 
      decreased or same as population risk (p = 0.1154). In the event they undergo 
      genomic risk testing again, 55 % of participants overall indicated they would 
      prefer to receive their results online compared to 28 % that would prefer to 
      receive future results in-person. Of those participants preferring to receive 
      results online, 77 % indicated they would prefer to have the option to speak to 
      someone if they had questions with the online results (compared to accessing 
      results online without the option of professional consultation). This is the 
      first study to assess satisfaction with genomic risk testing by the method of 
      delivery of the test result. The higher rate of trust in results delivered 
      in-person suggests that online access reports may not result in serious 
      consideration of results and lack of adoption of recommended preventive 
      recommendations.
FAU - Mills, Rachel
AU  - Mills R
AD  - Duke Institute for Genome Sciences & Policy, Duke University, 304 Research Drive, 
      Box 90141, Durham, NC, 27708, USA, r.mills@duke.edu.
FAU - Barry, William
AU  - Barry W
FAU - Haga, Susanne B
AU  - Haga SB
LA  - eng
GR  - R21 HL096573/HL/NHLBI NIH HHS/United States
GR  - 1R21HL096573-01A1/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20131203
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - Diabetes Mellitus, Type 2/*diagnosis/genetics/psychology
MH  - Humans
MH  - Patient Satisfaction
MH  - *Risk Assessment
MH  - *Trust
PMC - PMC4028379
MID - NIHMS545502
EDAT- 2013/12/03 06:00
MHDA- 2015/01/03 06:00
PMCR- 2015/06/01
CRDT- 2013/12/03 06:00
PHST- 2013/03/26 00:00 [received]
PHST- 2013/11/14 00:00 [accepted]
PHST- 2013/12/03 06:00 [entrez]
PHST- 2013/12/03 06:00 [pubmed]
PHST- 2015/01/03 06:00 [medline]
PHST- 2015/06/01 00:00 [pmc-release]
AID - 10.1007/s10897-013-9674-3 [doi]
PST - ppublish
SO  - J Genet Couns. 2014 Jun;23(3):401-8. doi: 10.1007/s10897-013-9674-3. Epub 2013 
      Dec 3.