PMID- 24293823
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131202
LR  - 20211021
IS  - 0970-2822 (Print)
IS  - 0974-0120 (Electronic)
IS  - 0970-2822 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Dec
TI  - Diversity of Hepatitis C virus in Southern India Based on 5'UTR Sequence.
PG  - 349-53
LID - 10.1007/s13337-012-0103-2 [doi]
AB  - Hepatitis C virus (HCV) exhibits genotype-specific variations in geographical 
      distribution as a consequence of drug and immune induced evolution. Present study 
      was aimed at discerning the distribution and prevalence of the various genotypes 
      and subtypes of HCV in southern India. The HCV positive patient's serum was 
      collected from different hospitals and blood banks from the states of Kerala, 
      Tamil Nadu, Andhra Pradesh and Karnataka. Among 114 HCV positive samples, we 
      could find only 44 isolates that are found both positive in ELISA and RT-PCR. 
      From these samples 5' untranslated region (5'UTR) were amplified, sequenced and 
      sub typed. Analysis of 5'UTR region of the 44 isolates shows that, genotypes 1, 
      3, 4 and 6 are present with genotype 3 being the most frequent. The present study 
      shows that HCV genotype 3 subtype B was the most prevalent, forming 47.7 % among 
      the population in southern India. The present study urges for discovering novel 
      therapeutic agents that should be specific to genotype 3 subtype B, for the 
      management of HCV in southern India.
FAU - Amjesh, R
AU  - Amjesh R
AD  - Department of Computational Biology and Bioinformatics, University of Kerala, 
      Thiruvananthapuram, 695581 Kerala India.
FAU - Nair, Achuthsankar S
AU  - Nair AS
FAU - Sugunan, V S
AU  - Sugunan VS
LA  - eng
PT  - Journal Article
DEP - 20120925
PL  - India
TA  - Indian J Virol
JT  - Indian journal of virology : an official organ of Indian Virological Society
JID - 8610330
PMC - PMC3550797
EDAT- 2013/12/03 06:00
MHDA- 2013/12/03 06:01
PMCR- 2013/12/01
CRDT- 2013/12/03 06:00
PHST- 2012/03/10 00:00 [received]
PHST- 2012/08/14 00:00 [accepted]
PHST- 2013/12/03 06:00 [entrez]
PHST- 2013/12/03 06:00 [pubmed]
PHST- 2013/12/03 06:01 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - 103 [pii]
AID - 10.1007/s13337-012-0103-2 [doi]
PST - ppublish
SO  - Indian J Virol. 2012 Dec;23(3):349-53. doi: 10.1007/s13337-012-0103-2. Epub 2012 
      Sep 25.