PMID- 24294213
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131202
LR  - 20211021
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 4
DP  - 2013
TI  - Complementarity of Binding Motifs is a General Property of HLA-A and HLA-B 
      Molecules and Does Not Seem to Effect HLA Haplotype Composition.
PG  - 374
LID - 10.3389/fimmu.2013.00374 [doi]
LID - 374
AB  - Different human leukocyte antigen (HLA) haplotypes (i.e., the specific 
      combinations of HLA-A, -B, -DR alleles inherited together from one parent) are 
      observed in different frequencies in human populations. Some haplotypes, like 
      HLA-A1-B8, are very frequent, reaching up to 10% in the Caucasian population, 
      while others are very rare. Numerous studies have identified associations between 
      HLA haplotypes and diseases, and differences in haplotype frequencies can in part 
      be explained by these associations: the stronger the association with a severe 
      (autoimmune) disease, the lower the expected HLA haplotype frequency. The peptide 
      repertoires of the HLA molecules composing a haplotype can also influence the 
      frequency of a haplotype. For example, it would seem advantageous to have HLA 
      molecules with non-overlapping binding specificities within a haplotype, as 
      individuals expressing such an haplotype would present a diverse set of peptides 
      from viruses and pathogenic bacteria on the cell surface. To test this 
      hypothesis, we collect the proteome data from a set of common viruses, and 
      estimate the total ligand repertoire of HLA class I haplotypes (HLA-A-B) using in 
      silico predictions. We compare the size of these repertoires to the HLA haplotype 
      frequencies reported in the National Marrow Donor Program (NMDP). We find that in 
      most HLA-A and HLA-B pairs have fairly distinct binding motifs, and that the 
      observed haplotypes do not contain HLA-A and -B molecules with more distinct 
      binding motifs than random HLA-A and HLA-B pairs. In addition, the population 
      frequency of a haplotype is not correlated to the distinctness of its HLA-A and 
      HLA-B peptide binding motifs. These results suggest that there is a not a strong 
      selection pressure on the haplotype level favoring haplotypes having HLA 
      molecules with distinct binding motifs, which would result the largest possible 
      presented peptide repertoires in the context of infectious diseases.
FAU - Rao, Xiangyu
AU  - Rao X
AD  - Theoretical Biology and Bioinformatics, Utrecht University , Utrecht , 
      Netherlands.
FAU - De Boer, Rob J
AU  - De Boer RJ
FAU - van Baarle, Debbie
AU  - van Baarle D
FAU - Maiers, Martin
AU  - Maiers M
FAU - Kesmir, Can
AU  - Kesmir C
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131114
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3827838
OTO - NOTNLM
OT  - HLA antigens
OT  - bioinformatics
OT  - computational biology
OT  - genetic
OT  - haplotypes
OT  - peptide binding
OT  - selection
EDAT- 2013/12/03 06:00
MHDA- 2013/12/03 06:01
PMCR- 2013/01/01
CRDT- 2013/12/03 06:00
PHST- 2013/07/23 00:00 [received]
PHST- 2013/10/31 00:00 [accepted]
PHST- 2013/12/03 06:00 [entrez]
PHST- 2013/12/03 06:00 [pubmed]
PHST- 2013/12/03 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2013.00374 [doi]
PST - epublish
SO  - Front Immunol. 2013 Nov 14;4:374. doi: 10.3389/fimmu.2013.00374. eCollection 
      2013.