PMID- 24295549 OWN - NLM STAT- MEDLINE DCOM- 20140318 LR - 20151119 IS - 1879-1913 (Electronic) IS - 0002-9149 (Linking) VI - 113 IP - 3 DP - 2014 Feb 1 TI - Usefulness of a combination of monocyte chemoattractant protein-1, galectin-3, and N-terminal probrain natriuretic peptide to predict cardiovascular events in patients with coronary artery disease. PG - 434-40 LID - S0002-9149(13)02141-3 [pii] LID - 10.1016/j.amjcard.2013.10.012 [doi] AB - Patients with coronary artery disease may develop not only ischemic events but also heart failure and death due to previous myocardial damage. The purpose of this study was to test the prognostic value of a panel of plasma biomarkers related to vascular (monocyte chemoattractant protein-1 [MCP-1] and soluble tumor necrosis factor-like weak inducer of apoptosis) and myocardial damage (galectin-3, N-terminal fragment of brain natriuretic peptide [NT-proBNP], and neutrophil gelatinase-associated lipocalin) in 706 patients with chronic coronary artery disease followed for 2.2 +/- 0.99 years. Secondary outcomes were the incidence of acute ischemic events (ST elevation myocardial infarction, non-ST elevation acute coronary syndrome, stroke, or transient ischemic attack) and death or heart failure. The primary outcome was the combination of the secondary outcomes. Cox proportional hazards model was used for analysis. Fifty-three patients developed acute ischemic events. Increasing MCP-1 plasma levels (p = 0.002), age, and body mass index predicted this outcome independently. Thirty-three patients developed death and/or heart failure. Galectin-3 (p = 0.007), NT-proBNP plasma levels (p = 0.004), hypertension, glomerular filtration rate, and the use of nitrates and anticoagulants were associated with this outcome independently. The development of the primary outcome was predicted independently by MCP-1 (p <0.001), NT-proBNP (p = 0.005), and galectin-3 (p = 0.019); hypertension; atrial fibrillation; and treatment with nitrates. Every biomarker with a value above the median increased the risk of developing this outcome by 1.832 (95% confidence interval 1.356 to 2.474, p <0.001). High-sensitivity C-reactive protein and lipid levels were not associated with any outcome. In conclusion, increasing MCP-1, galectin-3, and NT-proBNP plasma levels are associated with a greater incidence of cardiovascular events. CI - Copyright (c) 2014 Elsevier Inc. All rights reserved. FAU - Tunon, Jose AU - Tunon J AD - Department of Cardiology, IIS-Fundacion Jimenez Diaz, Madrid, Spain; Autonoma University, Madrid, Spain; Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion Jimenez Diaz, Madrid, Spain. Electronic address: jtunon@secardiologia.es. FAU - Blanco-Colio, Luis AU - Blanco-Colio L AD - Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion Jimenez Diaz, Madrid, Spain. FAU - Cristobal, Carmen AU - Cristobal C AD - Department of Cardiology, Hospital de Fuenlabrada, Madrid, Spain; Rey Juan Carlos University, Alcorcon, Madrid, Spain. FAU - Tarin, Nieves AU - Tarin N AD - Department of Cardiology, Hospital Universitario de Mostoles, Madrid, Spain. FAU - Higueras, Javier AU - Higueras J AD - Department of Cardiology, Hospital Clinico Universitario San Carlos, Madrid, Spain. FAU - Huelmos, Ana AU - Huelmos A AD - Department of Cardiology, Hospital Universitario Fundacion Alcorcon, Madrid, Spain. FAU - Alonso, Joaquin AU - Alonso J AD - Department of Cardiology, Hospital de Fuenlabrada, Madrid, Spain; Rey Juan Carlos University, Alcorcon, Madrid, Spain. FAU - Egido, Jesus AU - Egido J AD - Autonoma University, Madrid, Spain; Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion Jimenez Diaz, Madrid, Spain; Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas, Madrid, Spain. FAU - Asensio, Dolores AU - Asensio D AD - Department of Biochemistry, IIS-Fundacion Jimenez Diaz, Madrid, Spain. FAU - Lorenzo, Oscar AU - Lorenzo O AD - Autonoma University, Madrid, Spain; Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion Jimenez Diaz, Madrid, Spain. FAU - Mahillo-Fernandez, Ignacio AU - Mahillo-Fernandez I AD - Department of Preventive Medicine, IIS-Fundacion Jimenez Diaz, Madrid, Spain. FAU - Rodriguez-Artalejo, Fernando AU - Rodriguez-Artalejo F AD - Department of Preventive Medicine and Public Health, School of Medicine, Autonoma University, Madrid, Spain. FAU - Farre, Jeronimo AU - Farre J AD - Department of Cardiology, IIS-Fundacion Jimenez Diaz, Madrid, Spain; Autonoma University, Madrid, Spain. FAU - Martin-Ventura, Jose Luis AU - Martin-Ventura JL AD - Autonoma University, Madrid, Spain; Laboratory of Vascular Pathology, Instituto de Investigacion Sanitaria-Fundacion Jimenez Diaz, Madrid, Spain. FAU - Lopez-Bescos, Lorenzo AU - Lopez-Bescos L AD - Rey Juan Carlos University, Alcorcon, Madrid, Spain. LA - eng PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20131107 PL - United States TA - Am J Cardiol JT - The American journal of cardiology JID - 0207277 RN - 0 (Biomarkers) RN - 0 (Chemokine CCL2) RN - 0 (Galectin 3) RN - 0 (Peptide Fragments) RN - 0 (Protein Precursors) RN - 0 (pro-brain natriuretic peptide (1-76)) RN - 114471-18-0 (Natriuretic Peptide, Brain) SB - IM MH - Aged MH - Biomarkers/blood MH - Chemokine CCL2/*blood MH - Coronary Artery Disease/*blood/complications MH - Disease Progression MH - Electrocardiography MH - Female MH - Follow-Up Studies MH - Galectin 3/*blood MH - Heart Failure/blood/*epidemiology/etiology MH - Humans MH - Incidence MH - Male MH - Middle Aged MH - Natriuretic Peptide, Brain/*blood MH - Peptide Fragments/*blood MH - Protein Precursors MH - Retrospective Studies MH - Risk Factors MH - Spain/epidemiology MH - Stroke/blood/*epidemiology/etiology MH - Survival Rate/trends EDAT- 2013/12/04 06:00 MHDA- 2014/03/19 06:00 CRDT- 2013/12/04 06:00 PHST- 2013/09/05 00:00 [received] PHST- 2013/10/27 00:00 [revised] PHST- 2013/10/27 00:00 [accepted] PHST- 2013/12/04 06:00 [entrez] PHST- 2013/12/04 06:00 [pubmed] PHST- 2014/03/19 06:00 [medline] AID - S0002-9149(13)02141-3 [pii] AID - 10.1016/j.amjcard.2013.10.012 [doi] PST - ppublish SO - Am J Cardiol. 2014 Feb 1;113(3):434-40. doi: 10.1016/j.amjcard.2013.10.012. Epub 2013 Nov 7.