PMID- 24295645
OWN - NLM
STAT- MEDLINE
DCOM- 20150207
LR  - 20220330
IS  - 1876-4479 (Electronic)
IS  - 1873-9946 (Linking)
VI  - 8
IP  - 6
DP  - 2014 Jun
TI  - Tuberculosis infection following anti-TNF therapy in inflammatory bowel disease, 
      despite negative screening.
PG  - 550-7
LID - S1873-9946(13)00397-8 [pii]
LID - 10.1016/j.crohns.2013.11.008 [doi]
AB  - We present two patients with inflammatory bowel disease who, despite negative 
      tuberculosis screening, developed a de novo tuberculosis infection after the 
      start of anti tumor necrosis factor alpha treatment. We discuss current screening 
      methods and their limitations, the approach after positive screening and the 
      timing to resume anti-TNFalpha treatment after TB infection. We shortly mention the 
      immune reconstitution inflammatory syndrome (IRIS), described in a few cases 
      after the stop of anti-TNFalpha while treating the tuberculosis infection. We 
      conclude with some remaining questions concerning tuberculosis in IBD patients.
CI  - Copyright (c) 2013 European Crohn's and Colitis Organisation. Published by Elsevier 
      B.V. All rights reserved.
FAU - Debeuckelaere, Celine
AU  - Debeuckelaere C
AD  - Department of Internal Medicine, University Hospitals Leuven, Herestraat 49, 
      B-3000 Leuven, Belgium.
FAU - De Munter, Paul
AU  - De Munter P
AD  - Department of Infectious Diseases, University Hospitals Leuven, Herestraat 49, 
      B-3000 Leuven, Belgium.
FAU - Van Bleyenbergh, Pascal
AU  - Van Bleyenbergh P
AD  - Department of Respiratory Division, University Hospitals Leuven, Herestraat 49, 
      B-3000 Leuven, Belgium.
FAU - De Wever, Walter
AU  - De Wever W
AD  - Department of Radiology, University Hospitals Leuven, Herestraat 49, B-3000 
      Leuven, Belgium.
FAU - Van Assche, Gert
AU  - Van Assche G
AD  - Department of Gastroenterology, University Hospitals Leuven, Herestraat 49, 
      B-3000 Leuven, Belgium.
FAU - Rutgeerts, Paul
AU  - Rutgeerts P
AD  - Department of Gastroenterology, University Hospitals Leuven, Herestraat 49, 
      B-3000 Leuven, Belgium.
FAU - Vermeire, Severine
AU  - Vermeire S
AD  - Department of Gastroenterology, University Hospitals Leuven, Herestraat 49, 
      B-3000 Leuven, Belgium. Electronic address: Severine.Vermeire@uzleuven.be.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20131202
PL  - England
TA  - J Crohns Colitis
JT  - Journal of Crohn's & colitis
JID - 101318676
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - B72HH48FLU (Infliximab)
SB  - IM
MH  - Adult
MH  - Antibodies, Monoclonal/*adverse effects/therapeutic use
MH  - Colitis, Ulcerative/*complications/drug therapy
MH  - Crohn Disease/*complications/drug therapy
MH  - False Negative Reactions
MH  - Humans
MH  - Infliximab
MH  - Male
MH  - Middle Aged
MH  - Tuberculosis, Pulmonary/chemically induced/diagnosis/*etiology
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
OTO - NOTNLM
OT  - Anti-TNFalpha
OT  - Anti-tuberculous therapy
OT  - De novo tuberculosis
OT  - IBD
OT  - Immune reconstitution inflammatory syndrome
OT  - Screening
EDAT- 2013/12/04 06:00
MHDA- 2015/02/11 06:00
CRDT- 2013/12/04 06:00
PHST- 2012/04/21 00:00 [received]
PHST- 2013/11/07 00:00 [revised]
PHST- 2013/11/08 00:00 [accepted]
PHST- 2013/12/04 06:00 [entrez]
PHST- 2013/12/04 06:00 [pubmed]
PHST- 2015/02/11 06:00 [medline]
AID - S1873-9946(13)00397-8 [pii]
AID - 10.1016/j.crohns.2013.11.008 [doi]
PST - ppublish
SO  - J Crohns Colitis. 2014 Jun;8(6):550-7. doi: 10.1016/j.crohns.2013.11.008. Epub 
      2013 Dec 2.