PMID- 24296892
OWN - NLM
STAT- MEDLINE
DCOM- 20140728
LR  - 20211021
IS  - 0973-7138 (Electronic)
IS  - 0250-5991 (Linking)
VI  - 38
IP  - 5
DP  - 2013 Dec
TI  - ABCA1 C69T gene polymorphism and risk of type 2 diabetes mellitus in a Saudi 
      population.
PG  - 893-7
AB  - Type 2 diabetes mellitus (T2DM) is a disease induced by complex interactions 
      between environmental factors and certain genetic factors. Genetic variants in 
      the Adenosine Binding Cassette Transporter Proteins 1 (ABCA1) have been 
      associated with abnormalities of serum lipid levels of high-density lipoprotein 
      (HDL-C). Decreased serum levels of HDL-C have often been observed in T2DM cases, 
      and this condition has been considered to be involved in the mechanism of insulin 
      resistance (IR). Therefore, we investigated possible association between ABCA1 
      C69T gene polymorphism and T2DMin a Saudi population. This study was carried out 
      with 380 healthy control subjects and 376 T2DM patients. Genotyping of ABCA1 C69T 
      polymorphism was carried out by Polymerase Chain Reaction-Restriction Fragment 
      Length Polymorphism technique. We observed that the frequency of the T allele of 
      the ABCA1 C69T gene was significantly higher in healthy subjects compared to 
      T2DMpatients (0.28 vs 0.45; p less than 0.0001; OR (95 percent CI) = 0.4624 
      (0.3732-0.5729), and therefore the T allele may be a protective factor against 
      T2DM in the Saudi population.
FAU - Alharbi, Khalid K
AU  - Alharbi KK
AD  - Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, 
      King Saud University, P.O. Box 10219, Riyadh 11433, Kingdom of Saudi Arabia.
FAU - Khan, Imran Ali
AU  - Khan IA
FAU - Al-Daghri, Nasser M
AU  - Al-Daghri NM
FAU - Munshi, Anjana
AU  - Munshi A
FAU - Sharma, Vandana
AU  - Sharma V
FAU - Mohammed, Abdul Khader
AU  - Mohammed AK
FAU - Wani, Kaiser A
AU  - Wani KA
FAU - Al-Sheikh, Yazeed A
AU  - Al-Sheikh YA
FAU - Al-Nbaheen, May Salem
AU  - Al-Nbaheen MS
FAU - Ansari, Mohammed Ghouse Ahmed
AU  - Ansari MG
FAU - Syed, Rabbani
AU  - Syed R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - J Biosci
JT  - Journal of biosciences
JID - 8100809
RN  - 0 (ABCA1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter 1)
SB  - IM
MH  - ATP Binding Cassette Transporter 1/*genetics
MH  - Adult
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Risk
MH  - Saudi Arabia
MH  - Sequence Analysis, DNA
EDAT- 2013/12/04 06:00
MHDA- 2014/07/30 06:00
CRDT- 2013/12/04 06:00
PHST- 2013/12/04 06:00 [entrez]
PHST- 2013/12/04 06:00 [pubmed]
PHST- 2014/07/30 06:00 [medline]
AID - 10.1007/s12038-013-9384-x [doi]
PST - ppublish
SO  - J Biosci. 2013 Dec;38(5):893-7. doi: 10.1007/s12038-013-9384-x.