PMID- 24296955
OWN - NLM
STAT- MEDLINE
DCOM- 20160120
LR  - 20150428
IS  - 1542-233X (Electronic)
IS  - 1542-2321 (Linking)
VI  - 41
IP  - 3
DP  - 2015 May
TI  - Recurrent ocular surface inflammation associated with human herpesvirus 6 
      infection.
PG  - e11-3
LID - 10.1097/ICL.0b013e3182a70a1b [doi]
AB  - OBJECTIVES: To report a case of atypical herpes keratitis and bilateral 
      conjunctivitis associated with human herpesvirus 6 (HHV-6). METHODS: An 
      immunocompetent 34-year-old man was referred for herpetic epithelial keratitis in 
      his left eye, which was non-responsive to topical acyclovir. Biomicroscopy 
      revealed a central dendritic ulcer with a white stromal infiltrate beneath the 
      ulcer. RESULTS: The corneal scraping multiplex polymerase chain reaction (CLART 
      ENTHERPEX, Genomica, Spain) was positive for HHV-6 and negative for herpes 
      simplex virus, varicella zoster virus, cytomegalovirus, and Epstein-Barr virus. 
      An improvement of the keratitis and visual acuity was achieved with topical 
      fluorometholone and systemic valacyclovir. One year later, the patient complained 
      of redness of the eyes. A slit-lamp examination disclosed bilateral follicular 
      conjunctivitis, and HHV-6 DNA was once again detected in a conjunctival scraping 
      of both eyes. CONCLUSIONS: Human herpesvirus 6 may be another causative agent for 
      corneal ulcers and conjunctivitis in isolation. Stromal necrosis is a rare 
      manifestation of herpetic dendritic keratitis. In these cases, we should consider 
      the presence of HHV-6 in the differential diagnosis, even in immunocompetent 
      patients.
FAU - Boto-de-los-Bueis, Ana
AU  - Boto-de-los-Bueis A
AD  - Departments of Ophthalmology (A.B., A.D., E.G.S., S.M., S.N.); and Microbiology 
      (M.P.R.), La Paz University Hospital, IdiPaz, Madrid, Spain.
FAU - Romero Gomez, Maria P
AU  - Romero Gomez MP
FAU - del Hierro Zarzuelo, Almudena
AU  - del Hierro Zarzuelo A
FAU - Sanchez, Eugenia G
AU  - Sanchez EG
FAU - Mediero, Soraya
AU  - Mediero S
FAU - Noval, Susana
AU  - Noval S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Eye Contact Lens
JT  - Eye & contact lens
JID - 101160941
SB  - IM
MH  - Adult
MH  - Conjunctivitis, Viral/*virology
MH  - Herpesvirus 6, Human/*isolation & purification
MH  - Humans
MH  - Keratitis, Herpetic/*virology
MH  - Male
MH  - Recurrence
EDAT- 2013/12/04 06:00
MHDA- 2016/01/21 06:00
CRDT- 2013/12/04 06:00
PHST- 2013/12/04 06:00 [entrez]
PHST- 2013/12/04 06:00 [pubmed]
PHST- 2016/01/21 06:00 [medline]
AID - 10.1097/ICL.0b013e3182a70a1b [doi]
PST - ppublish
SO  - Eye Contact Lens. 2015 May;41(3):e11-3. doi: 10.1097/ICL.0b013e3182a70a1b.