PMID- 24299284
OWN - NLM
STAT- MEDLINE
DCOM- 20151006
LR  - 20181202
IS  - 0035-9351 (Print)
IS  - 0035-9351 (Linking)
VI  - 92
IP  - 11
DP  - 2013 Nov
TI  - [Multiple endocrine neoplasia type 1 syndrome with special emphasis on 
      pancreatoduodenal tumours--a case report analysis].
PG  - 625-33
AB  - INTRODUCTION: The syndrome of multiple endocrine neoplasia type 1 (MEN 1) is a 
      relatively rare hereditary disease predisposing to a variety of tumours, some of 
      which may be hormonally active. The main organs affected are the parathyroid, the 
      pituitary and the pancreatoduodenal area. Despite the rarity of MEN 1, its 
      occurrence is not negligible in clinical practice and the clinicians ignorance 
      often leads to delayed diagnosis and inadequate treatment. MATERIAL AND METHODS: 
      The aim of this review is to present contemporary literature on this issue, 
      including the most controversial topic, i.e. recent modalities of treatment of 
      pancreatoduodenal tumours, and to present a case report. The literature review 
      was based on computer searches in PubMed and DynaMed. DISCUSSION: 
      Pancreatoduodenal tumours associated with MEN 1 are relatively slow-growing 
      neoplasias. The development of liver metastases is the main factor of long-term 
      survival. The aim of surgical treatment is the stabilisation of the disease and 
      the prevention of liver metastases. Radical surgical methods may lead to better 
      biochemical curability. The extent of surgical intervention should be selected 
      individually. We discuss our case report in the context of these findings. 
      CONCLUSION: Knowledge of the MEN 1 syndrome has its importance in the clinical 
      practice. Further prospective studies will be needed to evaluate the 
      effectiveness of treatment, especially for pancreatoduodenal tumours.
FAU - Menclova, K
AU  - Menclova K
FAU - Ryska, M
AU  - Ryska M
LA  - cze
PT  - Case Reports
PT  - Journal Article
PT  - Review
TT  - Syndrom mnohocetne endokrinni neoplazie typu 1 se zvlastnim durazem na tumory 
      pankreatoduodenalni oblasti - rozbor vlastni kazuistiky.
PL  - Czech Republic
TA  - Rozhl Chir
JT  - Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti
JID - 9815441
SB  - IM
MH  - Duodenal Neoplasms/pathology/*therapy
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/pathology/*therapy
MH  - Pancreatic Neoplasms/pathology/*therapy
EDAT- 2013/12/05 06:00
MHDA- 2015/10/07 06:00
CRDT- 2013/12/05 06:00
PHST- 2013/12/05 06:00 [entrez]
PHST- 2013/12/05 06:00 [pubmed]
PHST- 2015/10/07 06:00 [medline]
AID - 43345 [pii]
PST - ppublish
SO  - Rozhl Chir. 2013 Nov;92(11):625-33.