PMID- 24300227
OWN - NLM
STAT- MEDLINE
DCOM- 20150512
LR  - 20191210
IS  - 1536-5409 (Electronic)
IS  - 0749-8047 (Linking)
VI  - 30
IP  - 10
DP  - 2014 Oct
TI  - The interleukin-1alpha gene C>T polymorphism rs1800587 is associated with increased 
      pain intensity and decreased pressure pain thresholds in patients with lumbar 
      radicular pain.
PG  - 869-74
LID - 10.1097/AJP.0000000000000048 [doi]
AB  - OBJECTIVES: Previous studies have suggested that many inflammatory cytokines, 
      including interleukin (IL)-1alpha, may be associated with lumbar radicular pain after 
      disk herniation. In the present study, we examined how variability of the IL-1alpha 
      gene affects pain intensity and the pressure pain threshold (PPT) in patients 
      with symptomatic disk herniation. MATERIALS AND METHODS: A total of 121 patients 
      with lumbar radicular pain due to disk herniation were recruited from Oslo 
      University Hospital, Norway, and followed up at 6 weeks and 12 months. The 
      primary outcome measures were pain intensity scores for the lower back and legs 
      using a visual analog pain scale (VAS) and PPT for the gluteal muscles. 
      Genotyping was carried out using a predesigned TaqMan assay for IL-1alpha rs1800587. 
      The effect of the IL-1alpha genotype on the VAS and PPT was analyzed by repeated 
      measure analyses of variance. RESULTS: The IL-1alpha gene C>T polymorphism rs1800587 
      affected VAS and PPT scores in patients with symptomatic disk herniation. 
      Patients with the CT/TT genotype reported a higher VAS leg pain intensity 
      (P=0.002) and also a lower PPT in the gluteal muscles (left P=0.016; right 
      P=0.016) compared with patients with the CC genotype during 1 year of follow-up. 
      DISCUSSION: The present data show that the IL-1alpha CT/TT genotype rs1800587 may be 
      associated with increased pain intensity and corresponding reduced PPT during the 
      first year after disk herniation.
FAU - Schistad, Elina I
AU  - Schistad EI
AD  - *Department of Physical Medicine and Rehabilitation, Oslo University Hospital, 
      Ullevaal daggerFaculty of Medicine  section signDepartment of Molecular Biosciences, University of 
      Oslo double daggerNational Institute of Occupational Health, Oslo, Norway.
FAU - Jacobsen, Line M
AU  - Jacobsen LM
FAU - Roe, Cecilie
AU  - Roe C
FAU - Gjerstad, Johannes
AU  - Gjerstad J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin J Pain
JT  - The Clinical journal of pain
JID - 8507389
RN  - 0 (Interleukin-1alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Association Studies
MH  - Genotype
MH  - Humans
MH  - Interleukin-1alpha/*genetics
MH  - Intervertebral Disc Displacement/*complications/*genetics/surgery
MH  - Leg/innervation
MH  - Lumbosacral Region
MH  - Male
MH  - Middle Aged
MH  - Outcome Assessment, Health Care
MH  - Pain/*etiology/genetics
MH  - Pain Threshold/*physiology
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Pressure/adverse effects
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2013/12/05 06:00
MHDA- 2015/05/13 06:00
CRDT- 2013/12/05 06:00
PHST- 2013/12/05 06:00 [entrez]
PHST- 2013/12/05 06:00 [pubmed]
PHST- 2015/05/13 06:00 [medline]
AID - 10.1097/AJP.0000000000000048 [doi]
PST - ppublish
SO  - Clin J Pain. 2014 Oct;30(10):869-74. doi: 10.1097/AJP.0000000000000048.