PMID- 24300595
OWN - NLM
STAT- MEDLINE
DCOM- 20141006
LR  - 20181202
IS  - 1941-7225 (Electronic)
IS  - 0895-7061 (Linking)
VI  - 27
IP  - 3
DP  - 2014 Mar
TI  - Effects of milk proteins and combined exercise training on aortic hemodynamics 
      and arterial stiffness in young obese women with high blood pressure.
PG  - 338-44
LID - 10.1093/ajh/hpt224 [doi]
AB  - BACKGROUND: Obesity and reduced muscle strength are associated with increased 
      blood pressure (BP). We examined the impact of milk proteins and combined 
      exercise training (CET) on BP, arterial function, and muscle strength 
      (one-repetition maximum (1-RM)). METHODS: Thirty-three obese sedentary women (age 
      = 30 +/- 1 years; body mass index = 35.2 +/- 0.9 kg/m(2); systolic BP (SBP) = 129 +/- 2 
      mm Hg) were randomized to control carbohydrate (n = 11), whey (n = 11), and 
      casein (n = 11) supplementation for 4 weeks. All participants performed 
      moderate-intensity CET 3 days/week. Brachial and aortic SBP, augmentation index 
      adjusted for 75 beats/minute (AIx@75), arterial stiffness (brachial-ankle pulse 
      wave velocity (baPWV)), and 1-RM were measured before and after the 
      interventions. RESULTS: There were significant (P < 0.05) time-by-group 
      interactions for brachial SBP (bSBP), aortic SBP (aSBP), AIx@75, and baPWV. Whey 
      and casein supplementation significantly (P < 0.05) decreased bSBP (approximately 
      5mm Hg for both), aSBP (approximately 7 mm Hg and approximately 6mm Hg, 
      respectively), AIx@75 (approximately 9.2% and approximately 8.1%, respectively) 
      and baPWV (approximately 57 cm/s and approximately 53 cm/s, respectively) 
      compared with no changes in the control group. Upper- (approximately 22.2%) and 
      lower-body 1-RM (approximately 44.0%) increased similarly in all groups. Changes 
      in arterial function and 1-RM were not correlated. CONCLUSIONS: Milk protein 
      supplementation with CET reduced SBP, wave reflection, and arterial stiffness in 
      young obese women with prehypertension and hypertension. Because CET did not 
      affect arterial function, milk proteins may have an antihypertensive effect by 
      improving arterial function, as shown by reduced AIx@75 and baPWV. Muscle 
      strength improvements after CET did not affect BP and arterial function. CLINICAL 
      TRIAL REGISTRATION: ClinicalTrial.gov Registration NCT01830946.
FAU - Figueroa, Arturo
AU  - Figueroa A
AD  - Department of Nutrition, Food and Exercise Sciences, Florida State University, 
      Tallahassee, Florida.
FAU - Wong, Alexei
AU  - Wong A
FAU - Kinsey, Amber
AU  - Kinsey A
FAU - Kalfon, Roy
AU  - Kalfon R
FAU - Eddy, Wyatt
AU  - Eddy W
FAU - Ormsbee, Michael J
AU  - Ormsbee MJ
LA  - eng
SI  - ClinicalTrials.gov/NCT01830946
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20131203
PL  - United States
TA  - Am J Hypertens
JT  - American journal of hypertension
JID - 8803676
RN  - 0 (Caseins)
RN  - 0 (Milk Proteins)
RN  - 0 (Whey Proteins)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aorta/*physiopathology
MH  - Caseins/*administration & dosage
MH  - *Dietary Supplements
MH  - Double-Blind Method
MH  - Female
MH  - Florida
MH  - *Hemodynamics
MH  - Humans
MH  - Hypertension/complications/diagnosis/physiopathology/*therapy
MH  - Milk Proteins/*administration & dosage
MH  - Muscle Strength
MH  - Muscle, Skeletal/physiopathology
MH  - Obesity/complications/diagnosis/physiopathology/*therapy
MH  - Pulse Wave Analysis
MH  - *Resistance Training
MH  - Sedentary Behavior
MH  - Sex Factors
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Vascular Stiffness
MH  - Whey Proteins
OTO - NOTNLM
OT  - aortic blood pressure
OT  - augmentation index
OT  - blood pressure
OT  - casein
OT  - hypertension
OT  - muscle strength
OT  - pulse wave velocity
OT  - wave reflection
OT  - whey.
EDAT- 2013/12/05 06:00
MHDA- 2014/10/07 06:00
CRDT- 2013/12/05 06:00
PHST- 2013/12/05 06:00 [entrez]
PHST- 2013/12/05 06:00 [pubmed]
PHST- 2014/10/07 06:00 [medline]
AID - hpt224 [pii]
AID - 10.1093/ajh/hpt224 [doi]
PST - ppublish
SO  - Am J Hypertens. 2014 Mar;27(3):338-44. doi: 10.1093/ajh/hpt224. Epub 2013 Dec 3.