PMID- 24300806
OWN - NLM
STAT- MEDLINE
DCOM- 20140123
LR  - 20161018
IS  - 1997-7298 (Print)
IS  - 1997-7298 (Linking)
VI  - 113
IP  - 10
DP  - 2013
TI  - [Interaction effects of anxiety and the BDNF Val66Met polymorphism on attention 
      in patients with schizophrenia spectrum disorders].
PG  - 49-54
AB  - Authors investigated effects of the Val66Met polymorphism of the brain-derived 
      neurotrophic factor (BDNF) gene and level of trait anxiety on attention in 90 
      patients with schizophrenia or schizoaffective psychosis. Attention was assessed 
      using auditory event-related brain potentials (ERPs) and neuropsychological 
      testing. There was a significant effect of the BDNF genotype, but not anxiety, on 
      performance on the neuropsychological test and on the P300 amplitude in frontal 
      and temporal leads. Carriers of a Met allele performed worse and showed lower 
      P300 amplitude during the attention task than those with the ValVal genotype. The 
      interaction effect of the genotype and anxiety was observed for non-target N100 
      amplitude in central and parietal leads. This effect depended on the level of 
      anxiety: the interaction was significant only in the group with the lower level 
      of anxiety. In this group, a Met allele was associated with the lower N100 
      amplitude. It was suggested that BDNF genotype does not contribute to brain 
      electrical activity at the first stage of stimulus recognition (N100) because 
      highly anxious people tend to be more attentive, regardless of genotype, due to 
      the fear about their ability to cope with the task requirements.
FAU - Golimbet, V E
AU  - Golimbet VE
FAU - Lebedeva, I S
AU  - Lebedeva IS
FAU - Alfimova, M V
AU  - Alfimova MV
FAU - Korovaitseva, G I
AU  - Korovaitseva GI
FAU - Lezheiko, T V
AU  - Lezheiko TV
LA  - rus
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PL  - Russia (Federation)
TA  - Zh Nevrol Psikhiatr Im S S Korsakova
JT  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
JID - 9712194
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adult
MH  - Anxiety/etiology/*genetics/metabolism
MH  - *Attention
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - DNA/*genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
MH  - *Polymorphism, Genetic
MH  - Schizophrenia/complications/*genetics/metabolism
MH  - Young Adult
EDAT- 2013/12/05 06:00
MHDA- 2014/01/24 06:00
CRDT- 2013/12/05 06:00
PHST- 2013/12/05 06:00 [entrez]
PHST- 2013/12/05 06:00 [pubmed]
PHST- 2014/01/24 06:00 [medline]
PST - ppublish
SO  - Zh Nevrol Psikhiatr Im S S Korsakova. 2013;113(10):49-54.