PMID- 24301752
OWN - NLM
STAT- MEDLINE
DCOM- 20150220
LR  - 20220408
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 12
IP  - 4
DP  - 2013 Oct 24
TI  - BDNF Val66Met polymorphism and serum concentrations of BDNF with smoking in Thai 
      males.
PG  - 4925-33
LID - 10.4238/2013.October.24.3 [doi]
AB  - Many studies have suggested that brain-derived neurotrophic factor (BDNF) is 
      involved in the reward system of addiction, and that nicotine may induce 
      alterations in BDNF gene expression and its protein level within the 
      mesocorticolimbic system. We investigated the BDNF levels and 
      biochemical-hematological parameters of smoker and non-smoker groups, and 
      examined the association of the Val66Met BDNF gene polymorphism with BDNF serum 
      levels and cigarette smoking. The study sample comprised 311 Thai volunteers (200 
      smokers; 111 non-smokers). The levels of serum BDNF and biochemical-hematological 
      parameters were determined. The Val66Met BDNF polymorphism was genotyped by the 
      polymerase chain reaction-restriction fragment length polymorphism technique. The 
      smoker group had significantly higher serum BDNF levels than the non-smoker group 
      (8.3 vs 6.5 ng/mL, P < 0.05). BDNF concentrations correlated positively with 
      hemoglobin, hematocrit, red blood cell count, white blood cell count, platelet 
      count, number of cigarettes smoked, and thiocyanate level (P < 0.05). No 
      association was found between the BDNF Val66Met genotype and the serum BDNF 
      level. The BDNF Val66Met polymorphism was not significantly associated with the 
      smoking status of the Thai males in this study. Cigarette smoking may be one 
      factor that determines the serum BDNF level, but the BDNF Val66Met polymorphism 
      probably does not influence susceptibility to smoking among Thai males.
FAU - Suriyaprom, K
AU  - Suriyaprom K
AD  - Faculty of Medical Technology, Rangsit University, Pathumthani, Thailand 
      kanjana.su@rsu.ac.th.
FAU - Tungtrongchitr, R
AU  - Tungtrongchitr R
FAU - Thawnashom, K
AU  - Thawnashom K
FAU - Pimainog, Y
AU  - Pimainog Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131024
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - *Alleles
MH  - Brain-Derived Neurotrophic Factor/*blood/*genetics
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - *Population Surveillance
MH  - Risk Factors
MH  - *Smoking
MH  - Thailand
MH  - Young Adult
EDAT- 2013/12/05 06:00
MHDA- 2015/02/24 06:00
CRDT- 2013/12/05 06:00
PHST- 2013/12/05 06:00 [entrez]
PHST- 2013/12/05 06:00 [pubmed]
PHST- 2015/02/24 06:00 [medline]
AID - gmr2948 [pii]
AID - 10.4238/2013.October.24.3 [doi]
PST - epublish
SO  - Genet Mol Res. 2013 Oct 24;12(4):4925-33. doi: 10.4238/2013.October.24.3.