PMID- 2430230
OWN - NLM
STAT- MEDLINE
DCOM- 19861212
LR  - 20190726
IS  - 0028-3908 (Print)
IS  - 0028-3908 (Linking)
VI  - 25
IP  - 9
DP  - 1986 Sep
TI  - Analysis by HPLC-EC of metabolites of monoamines in fetal and postnatal rat 
      brain.
PG  - 981-6
AB  - High performance liquid chromatography with electrochemical detection (HPLC-EC) 
      was adapted for the analysis of metabolites of monoamines (MA) in the developing 
      brain of the rat. 3-Methoxy-4-hydroxy-phenyl-ethylene glycol (MOPEG), dihydroxy 
      phenylacetic acid (DOPAC), homovanillic acid (HVA) and 5-hydroxy-3-indoleacetic 
      acid (5-HIAA) were found in significant amounts in forebrain of the foetal rat 
      from gestational day (GD) 17. The development pattern of the four metabolites was 
      essentially similar in male and female animals. Except for transient fluctuations 
      at around birth, concentrations of metabolites increased gradually throughout 
      late gestation and early postnatal life. In late gestation and at birth the 
      absolute amounts were small, while the concentrations were comparable to adult 
      levels.
FAU - Ribary, U
AU  - Ribary U
FAU - Schlumpf, M
AU  - Schlumpf M
FAU - Lichtensteiger, W
AU  - Lichtensteiger W
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuropharmacology
JT  - Neuropharmacology
JID - 0236217
RN  - 0 (Amines)
RN  - 102-32-9 (3,4-Dihydroxyphenylacetic Acid)
RN  - 534-82-7 (Methoxyhydroxyphenylglycol)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - X77S6GMS36 (Homovanillic Acid)
SB  - IM
MH  - 3,4-Dihydroxyphenylacetic Acid/analysis
MH  - Amines/*metabolism
MH  - Animals
MH  - Animals, Newborn/*metabolism
MH  - Brain/*embryology
MH  - *Brain Chemistry
MH  - Chromatography, High Pressure Liquid
MH  - Female
MH  - Homovanillic Acid/analysis
MH  - Hydroxyindoleacetic Acid/analysis
MH  - Methoxyhydroxyphenylglycol/analysis
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1986/09/01 00:00
MHDA- 1986/09/01 00:01
CRDT- 1986/09/01 00:00
PHST- 1986/09/01 00:00 [pubmed]
PHST- 1986/09/01 00:01 [medline]
PHST- 1986/09/01 00:00 [entrez]
AID - 10.1016/0028-3908(86)90191-7 [doi]
PST - ppublish
SO  - Neuropharmacology. 1986 Sep;25(9):981-6. doi: 10.1016/0028-3908(86)90191-7.