PMID- 24303105
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131204
LR  - 20211021
IS  - 2051-817X (Print)
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 1
IP  - 2
DP  - 2013 Jul
TI  - Thermoregulatory, cardiovascular, and metabolic responses to mild caloric 
      restriction in the Brown Norway rat.
PG  - e00016
LID - 10.1002/phy2.16 [doi]
LID - e00016
AB  - Caloric restriction (CR) has been demonstrated to prolong the life span of a 
      variety of species. CR-induced reduction in core temperature (Tc) is considered a 
      key mechanism responsible for prolonging life span in rodents; however, little is 
      known about the regulation of CR-induced hypothermia as a function of the 
      circadian cycle. We assessed how mild CR that resulted in a 10% reduction in body 
      weight affected the 24 h patterns of Tc as well as heart rate (HR) and motor 
      activity (MA) of the Brown Norway rat. Telemetered rats were allowed to feed for 
      20 weeks ad libitum (AL) or given a CR diet. Tc, HR, and MA of CR rats exhibited 
      nocturnal reductions and diurnal elevations, opposite to that of AL rats. The 
      effects of CR appeared to peak at  approximately 4 weeks. Metabolic rate (MR) and respiratory 
      exchange ratio (RER) were measured overnight after 18 weeks of CR. MR and RER 
      were elevated markedly at the time of feeding in CR rats and then declined during 
      the night. We found that the pattern of Tc was altered with CR, characterized by 
      elimination of high nocturnal Tc's typically observed in AL animals. In terms of 
      mechanisms to prolong life span in CR animals, we suggest that the shift in the 
      pattern of Tc during CR (i.e., elimination of high Tc's) may be as critical as 
      the overall mean reduction in Tc. Future studies should address how the time of 
      feeding may affect the thermoregulatory response in calorically restricted rats.
FAU - Aydin, Cenk
AU  - Aydin C
AD  - Department of Physiology, Faculty of Veterinary Medicine, University of Uludag 
      Nilufer, Bursa, 16509, Turkey.
FAU - Gordon, Christopher J
AU  - Gordon CJ
LA  - eng
PT  - Journal Article
DEP - 20130628
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
PMC - PMC3831912
OTO - NOTNLM
OT  - Caloric restriction
OT  - longevity
OT  - metabolic rate
OT  - radiotelemetry
OT  - thermoregulation
EDAT- 2013/12/05 06:00
MHDA- 2013/12/05 06:01
PMCR- 2013/07/01
CRDT- 2013/12/05 06:00
PHST- 2013/05/16 00:00 [received]
PHST- 2013/05/23 00:00 [revised]
PHST- 2013/05/29 00:00 [accepted]
PHST- 2013/12/05 06:00 [entrez]
PHST- 2013/12/05 06:00 [pubmed]
PHST- 2013/12/05 06:01 [medline]
PHST- 2013/07/01 00:00 [pmc-release]
AID - 10.1002/phy2.16 [doi]
PST - ppublish
SO  - Physiol Rep. 2013 Jul;1(2):e00016. doi: 10.1002/phy2.16. Epub 2013 Jun 28.