PMID- 24303168
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131204
LR  - 20240323
IS  - 2051-817X (Print)
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 1
IP  - 5
DP  - 2013 Oct
TI  - Multigenerational effects of fetal-neonatal iron deficiency on hippocampal BDNF 
      signaling.
PG  - e00096
LID - 10.1002/phy2.96 [doi]
LID - e00096
AB  - Fetal-neonatal iron deficiency induces adult learning impairments concomitant 
      with changes in expression of key genes underlying hippocampal learning and 
      memory in spite of neonatal iron replenishment. Notably, expression of 
      brain-derived neurotrophic factor (BDNF), a gene critical for neuronal maturation 
      and synaptic plasticity, is lowered both acutely and in adulthood following 
      early-life iron deficiency. Although the mechanism behind its long-term 
      downregulation remains unclear, epigenetic modification in BDNF, as seen in other 
      models of early-life adversity, may play a role. Given that early iron deficiency 
      occurs during critical periods in both hippocampal and gonadal development, we 
      hypothesized that the iron-sufficient offspring (F2 IS) of formerly 
      iron-deficient (F1 FID) rats would show a similar suppression of the BDNF gene as 
      their parents. We compared hippocampal mRNA levels of BDNF and functionally 
      related genes among F1 IS, F1 ID, and F2 IS male rats at postnatal day (P) 15 and 
      P65 using RT-qPCR. As expected, the F1 ID group showed a downregulation of BDNF 
      and associated genes acutely at P15 and chronically at P65. However, the F2 IS 
      group showed an upregulation of these genes at P15, returning to control levels 
      at P65. These results demonstrate that adverse effects of early iron deficiency 
      on hippocampal gene expression observed in the F1 are not present in the F2 
      generation, suggesting differential effects of nutritionally induced epigenetic 
      programing during the critical periods of hippocampal and gonadal development.
FAU - Blegen, Mariah B
AU  - Blegen MB
AD  - Department of Pediatrics, University of Minnesota Minneapolis, 55455, Minnesota.
FAU - Kennedy, Bruce C
AU  - Kennedy BC
FAU - Thibert, Katie A
AU  - Thibert KA
FAU - Gewirtz, Jonathan C
AU  - Gewirtz JC
FAU - Tran, Phu V
AU  - Tran PV
FAU - Georgieff, Michael K
AU  - Georgieff MK
LA  - eng
GR  - R01 HD029421/HD/NICHD NIH HHS/United States
GR  - T32 DA007097/DA/NIDA NIH HHS/United States
PT  - Journal Article
DEP - 20131002
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
PMC - PMC3841032
OTO - NOTNLM
OT  - Development
OT  - JARID
OT  - epigenetics
OT  - nutrition
OT  - rat
EDAT- 2013/12/05 06:00
MHDA- 2013/12/05 06:01
PMCR- 2013/10/01
CRDT- 2013/12/05 06:00
PHST- 2013/08/21 00:00 [received]
PHST- 2013/08/29 00:00 [accepted]
PHST- 2013/12/05 06:00 [entrez]
PHST- 2013/12/05 06:00 [pubmed]
PHST- 2013/12/05 06:01 [medline]
PHST- 2013/10/01 00:00 [pmc-release]
AID - 10.1002/phy2.96 [doi]
PST - ppublish
SO  - Physiol Rep. 2013 Oct;1(5):e00096. doi: 10.1002/phy2.96. Epub 2013 Oct 2.