PMID- 24303350
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131204
LR  - 20211021
IS  - 2233-6567 (Print)
IS  - 2233-6567 (Electronic)
IS  - 2233-6567 (Linking)
VI  - 28
DP  - 2013
TI  - Effects of Nano-sized Carbon Black on the Lungs of High Fat-diet Induced 
      Overweight Rats.
PG  - e2013014
LID - 10.5620/eht.2013.28.e2013014 [doi]
LID - e2013014
AB  - OBJECTIVES: This study was conducted to determine whether nano-sized carbon black 
      exposure results in greater damage in high fat diet-induced overweight rats than 
      normal weight ones and to identify the possible causes of any differences. 
      METHODS: Two groups of Sprague-Dawley rats allocated by body weight (normal and 
      overweight) were exposed to aerosolized nano-sized carbon black for 6 hours a 
      day, 5 days per week over a 4-week period. Differential cell counts, lactate 
      dehydrogenase (LDH) activities and albumin concentrations were measured in 
      bronchoalveolar lavage (BAL) fluid, and histopathological findings in the lungs 
      were evaluated. Tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6 were 
      measured in BAL fluid and supernatants of lipopolysaccharide(LPS)-stimulated 
      lymphocyte culture. RESULTS: Rats exposed to high concentrations of nano-sized 
      carbon black showed significantly increased (p<0.05) polymorphonuclear leukocyte 
      number and LDH activity in the BAL fluid from both overweight and normal rats. 
      Mild histopathological changes were observed in normal rats irrespective of 
      carbon black concentrations. However, severe histological scores were found in 
      overweight rats (1.75+/-0.46, 2.25+/-0.46, and 2.88+/-0.35 after low, medium, and high 
      concentration exposures). Proinflammatory cytokine levels of TNF-alpha and IL-6 were 
      significantly higher in the supernatant of LPS-stimulated lymphocytes of 
      overweight rats, whereas there was no significant difference in the BAL fluid 
      between normal and overweight rats. CONCLUSIONS: Inflammation and damage to lungs 
      exposed to nano-sized carbon black was more severe in high fat diet-induced 
      overweight rats compared to normal rats.
FAU - Lim, Cheol-Hong
AU  - Lim CH
AD  - Center for Chemicals Safety and Health Research, Occupational Safety and Health 
      Research Institute, KOSHA, Daejeon, Korea.
FAU - Kang, Mingu
AU  - Kang M
FAU - Han, Jeong-Hee
AU  - Han JH
FAU - Yun, Hyo-In
AU  - Yun HI
LA  - eng
PT  - Journal Article
DEP - 20131122
PL  - Korea (South)
TA  - Environ Health Toxicol
JT  - Environmental health and toxicology
JID - 101570455
PMC - PMC3842451
OTO - NOTNLM
OT  - Carbon black
OT  - Inhalation
OT  - Nano
OT  - Obesity
COIS- The authors have no conflicts of interest with material presented in this paper.
EDAT- 2013/12/05 06:00
MHDA- 2013/12/05 06:01
PMCR- 2013/11/22
CRDT- 2013/12/05 06:00
PHST- 2013/06/26 00:00 [received]
PHST- 2013/09/16 00:00 [accepted]
PHST- 2013/12/05 06:00 [entrez]
PHST- 2013/12/05 06:00 [pubmed]
PHST- 2013/12/05 06:01 [medline]
PHST- 2013/11/22 00:00 [pmc-release]
AID - 10.5620/eht.2013.28.e2013014 [doi]
PST - epublish
SO  - Environ Health Toxicol. 2013 Nov 22;28:e2013014. doi: 
      10.5620/eht.2013.28.e2013014. eCollection 2013.