PMID- 24304122
OWN - NLM
STAT- MEDLINE
DCOM- 20141012
LR  - 20140113
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 15
IP  - 1
DP  - 2014 Jan
TI  - Functional outcome and quality of life in Tourette's syndrome after deep brain 
      stimulation of the posteroventrolateral globus pallidus internus: long-term 
      follow-up.
PG  - 66-75
LID - 10.3109/15622975.2013.849004 [doi]
AB  - OBJECTIVES: Deep brain stimulation (DBS) for Tourette's syndrome (TS) in various 
      targets has been in the focus for some years. However, there are hardly any data 
      on "psychosocial" outcome after DBS for TS. The aim of the present study 
      therefore was to focus on the functional outcome and "psychosocial changes" in TS 
      patients after DBS. METHODS: Six patients with treatment-refractory TS underwent 
      GPi-DBS. The Yale Global Tic Severity Scale (YGTSS) was used to evaluate 
      symptomatic outcome. Psychosocial changes were assessed applying the Global 
      Assessment of Functioning Scale (GAF) and the Gilles-de-la-Tourette-Syndrome 
      Quality-of-Life scale (GTS-QOL) with additionally documenting psychosocial 
      changes. Follow-up ranged between 12 and 72 months. RESULTS: In all symptomatic 
      responders (4 of 6) we found a significant functional improvement (mean GAF 
      increasing from 53.75 (+/- 7.5) pre-operatively to 83.75 (+/- 7.5) at last follow-up) 
      along with a positive correlation with the course of GTS-QOL (R(2) = 0.62). 
      CONCLUSIONS: Treatment success should not only be assessed with the classic 
      "tic-scales", but also with the GAF and GTS-QOL. Although improvement of tics 
      seems to be positively correlated with improved functional outcome, symptomatic 
      improvement may lead to unexpected major psychosocial changes - which both the 
      patient and the clinicians in charge - should be prepared for.
FAU - Dehning, Sandra
AU  - Dehning S
AD  - Department of Psychiatry and Psychotherapy, Ludwig Maximilian University , Munich 
      , Germany.
FAU - Leitner, Bianka
AU  - Leitner B
FAU - Schennach, Rebecca
AU  - Schennach R
FAU - Muller, Norbert
AU  - Muller N
FAU - Botzel, Kai
AU  - Botzel K
FAU - Obermeier, Michael
AU  - Obermeier M
FAU - Mehrkens, Jan-Hinnerk
AU  - Mehrkens JH
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20131205
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
SB  - IM
MH  - Adult
MH  - Deep Brain Stimulation/instrumentation/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - Globus Pallidus/*physiology/surgery
MH  - Humans
MH  - Male
MH  - Quality of Life/*psychology
MH  - Severity of Illness Index
MH  - Stereotaxic Techniques/instrumentation
MH  - Tourette Syndrome/*therapy
MH  - Treatment Outcome
EDAT- 2013/12/07 06:00
MHDA- 2014/10/13 06:00
CRDT- 2013/12/06 06:00
PHST- 2013/12/06 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2014/10/13 06:00 [medline]
AID - 10.3109/15622975.2013.849004 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2014 Jan;15(1):66-75. doi: 10.3109/15622975.2013.849004. 
      Epub 2013 Dec 5.