PMID- 24305753
OWN - NLM
STAT- MEDLINE
DCOM- 20150120
LR  - 20131205
IS  - 1201-5989 (Print)
IS  - 1201-5989 (Linking)
VI  - 18
IP  - 7
DP  - 2013 Nov-Dec
TI  - Chronic urticaria and autoimmunity.
PG  - 5-9
AB  - Chronic urticaria is defined as hives, typically occurring daily, for greater 
      than 6 weeks duration. Chronic idiopathic urticaria, which has no discernable 
      external cause, comprises the majority of cases of chronic urticaria. Over half 
      of all cases of chronic idiopathic urticaria are thought to occur by an 
      autoimmune mechanism, primarily autoantibodies against the high affinity 
      immunoglobulin E (IgE) receptor (FcepsilonRI). Chronic urticaria is hypothesized to 
      occur because of a predilection in the patient to develop reactions to self. 
      Supporting this hypothesis, a strong association has been found between chronic 
      urticaria and additional autoimmune diseases, such as thyroid disease, rheumatoid 
      arthritis, systemic lupus erythematosus, Sjogren's syndrome, celiac disease and 
      type 1 diabetes, among others. Herein, we review the associations between chronic 
      urticaria, thyroid disease, and other autoimmune disorders, as well as the 
      implications that these correlations hold for therapeutic intervention in chronic 
      urticaria.
FAU - Fraser, Kathleen
AU  - Fraser K
AD  - College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Section 
      of Dermatology, Department of Medicine, University of Calgary, Calgary, AB, 
      Canada.
FAU - Robertson, Lynne
AU  - Robertson L
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Canada
TA  - Skin Therapy Lett
JT  - Skin therapy letter
JID - 9891441
SB  - IM
MH  - *Autoimmunity
MH  - Chronic Disease
MH  - Humans
MH  - Thyroid Diseases/complications/immunology
MH  - Urticaria/drug therapy/*immunology
EDAT- 2013/12/07 06:00
MHDA- 2015/01/21 06:00
CRDT- 2013/12/06 06:00
PHST- 2013/12/06 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2015/01/21 06:00 [medline]
AID - angioedema, antibodies, autoimmune disease, chronic disease, comorbidities, 
      complications, hives, hypersensitivity, inflammation, thyroid disease, urticaria 
      [pii]
PST - ppublish
SO  - Skin Therapy Lett. 2013 Nov-Dec;18(7):5-9.