PMID- 24307768
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131205
LR  - 20240413
IS  - 0973-2063 (Print)
IS  - 0973-2063 (Electronic)
IS  - 0973-2063 (Linking)
VI  - 9
IP  - 18
DP  - 2013
TI  - Agonistic approach of omega-3, omega-6 and its metabolites with BDNF: An 
      in-silico study.
PG  - 908-11
LID - 10.6026/97320630009908 [doi]
AB  - Brain derived neurotrophic factor (BDNF) is a member of neurotrophic family of 
      growth factors, mainly found in the hippocampus and cerebral cortex of brain. 
      Studies have shown that there is a link between BDNF and cognitive dysfunction, 
      as well as there is a relationship between the PUFAs intake and their effect on 
      BDNF production. Intake of PUFAs, mainly omega-3 and omega-6 has show increase in 
      production of BDNF in brain. In our study we performed docking studies on PUFAs 
      and their metabolites with BDNF using MVD (Molegro Virtual Docker), this has 
      shown that the metabolites of the PUFAs mainly LXA_4, NPD1, HDHA have shown more 
      binding affinity towards BDNF. These metabolites of PUFAs are responsible for 
      modulation of BDNF activity.
FAU - Kumar, Yadla Phani
AU  - Kumar YP
AD  - C R RAO Advanced Institute of Mathematics Statistics and Computer Science, 
      University of Hyderabad campus, Gachibowli, Hyderabad-500046.
FAU - Srinivas, G Sri Shanmukha
AU  - Srinivas GS
FAU - E, Yadu Mitravinda
AU  - E YM
FAU - Malla, Lalitha
AU  - Malla L
FAU - Rao, Allam Appa
AU  - Rao AA
LA  - eng
PT  - Journal Article
DEP - 20131111
PL  - Singapore
TA  - Bioinformation
JT  - Bioinformation
JID - 101258255
PMC - PMC3842576
OTO - NOTNLM
OT  - BDNF
OT  - Cognitive dysfunction
OT  - Escore
OT  - Evolutionary algorithm
OT  - HDHA
OT  - LXA_4
OT  - MVD
OT  - NPD1
OT  - PUFA
OT  - cavity detection algorithm
EDAT- 2013/12/07 06:00
MHDA- 2013/12/07 06:01
PMCR- 2013/01/01
CRDT- 2013/12/06 06:00
PHST- 2013/10/04 00:00 [received]
PHST- 2013/10/19 00:00 [accepted]
PHST- 2013/12/06 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2013/12/07 06:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 97320630009908 [pii]
AID - 10.6026/97320630009908 [doi]
PST - epublish
SO  - Bioinformation. 2013 Nov 11;9(18):908-11. doi: 10.6026/97320630009908. 
      eCollection 2013.