PMID- 24308275 OWN - NLM STAT- MEDLINE DCOM- 20140910 LR - 20180816 IS - 1744-8360 (Electronic) IS - 1473-7175 (Linking) VI - 14 IP - 1 DP - 2014 Jan TI - The relationship between neurotrophins and bipolar disorder. PG - 51-65 LID - 10.1586/14737175.2014.863709 [doi] AB - Relationship between neurotrophins, especially brain-derived neurotrophic factor (BDNF) and bipolar disorder (BPD) has been widely investigated, but results have been inconsistent. BDNF polymorphism may be associated with the susceptibility to subtype BPD such as rapid cycling BPD or early onset BPD. Met allele carriers of Val66Met of BDNF gene had smaller gray matter (GM) in both patients and healthy controls, but bipolar patients carrying Met allele had better response to lithium treatment. Decreased serum/plasma BDNF levels were observed at different mood states. BDNF may interact with other systems to execute its neuroprotective effects. Overall data suggest that neurotrophins may be involved in the pathogenesis of BPD and treatment response, but the magnitude of their role needs further investigation with large sample size studies. FAU - Wu, Renrong AU - Wu R AD - Institute of Mental Health of Second Xiangya Hospital, South Central University, Changsha 410011, Hunan, P.R. China. FAU - Fan, Jinbo AU - Fan J FAU - Zhao, Jingping AU - Zhao J FAU - Calabrese, Joseph R AU - Calabrese JR FAU - Gao, Keming AU - Gao K LA - eng PT - Journal Article PT - Review DEP - 20131122 PL - England TA - Expert Rev Neurother JT - Expert review of neurotherapeutics JID - 101129944 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Animals MH - Bipolar Disorder/*genetics MH - Brain-Derived Neurotrophic Factor/*genetics MH - Genetic Predisposition to Disease/*genetics MH - Humans MH - Nerve Growth Factors/genetics EDAT- 2013/12/07 06:00 MHDA- 2014/09/11 06:00 CRDT- 2013/12/07 06:00 PHST- 2013/12/07 06:00 [entrez] PHST- 2013/12/07 06:00 [pubmed] PHST- 2014/09/11 06:00 [medline] AID - 10.1586/14737175.2014.863709 [doi] PST - ppublish SO - Expert Rev Neurother. 2014 Jan;14(1):51-65. doi: 10.1586/14737175.2014.863709. Epub 2013 Nov 22.