PMID- 24308664
OWN - NLM
STAT- MEDLINE
DCOM- 20160427
LR  - 20181202
IS  - 1865-1682 (Electronic)
IS  - 1865-1674 (Linking)
VI  - 62
IP  - 5
DP  - 2015 Oct
TI  - Comparative Analysis of Immune Responses in Pigs to High and Low Pathogenic 
      Porcine Reproductive and Respiratory Syndrome Viruses Isolated in China.
PG  - e1-e10
LID - 10.1111/tbed.12190 [doi]
AB  - The CH-1a and HuN4 strains of porcine reproductive and respiratory syndrome virus 
      (PRRSV) show different pathogenicities in pigs. To understand host immune 
      responses against these viruses, we investigated the dynamic changes in cytokine 
      levels produced in peripheral blood of piglets infected with the highly 
      pathogenic PRRSV HuN4 strain or the CH-1a strain. Clinical signs, virus loads and 
      serum cytokine levels [interferon(IFN)-alpha, Interleukin (IL)-1, TNF-alpha, IL-6, IL-12, 
      IFN-gamma, IL-10 and TGF-beta] were tested. The results showed that while piglets 
      developed effective cellular immune responses against CH-1a infection, those 
      infected with HuN4 displayed ineffective cellular immunity, organ lesions and 
      persistent elevated levels of immunoregulatory cytokines (IL-10 and TGF-beta), which 
      delayed the development of PRRSV-specific immune responses. These results 
      demonstrated that HuN4 infection induced higher cytokine levels than that of 
      CH-1a infection induced. The changes in inflammatory cytokines intensified the 
      inflammatory reaction and damaged the tissues and organs.
CI  - (c) 2013 Blackwell Verlag GmbH.
FAU - Han, Z
AU  - Han Z
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
AD  - College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
FAU - Liu, Y
AU  - Liu Y
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Wang, G
AU  - Wang G
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - He, Y
AU  - He Y
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Hu, S
AU  - Hu S
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Li, Y
AU  - Li Y
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Shi, W
AU  - Shi W
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Wu, J
AU  - Wu J
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Wang, S
AU  - Wang S
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Liu, H
AU  - Liu H
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
FAU - Cai, X
AU  - Cai X
AD  - State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute of Chinese Academy of Agricultural Sciences, Harbin, China.
LA  - eng
SI  - GENBANK/EF635006
SI  - GENBANK/EU807840
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131206
PL  - Germany
TA  - Transbound Emerg Dis
JT  - Transboundary and emerging diseases
JID - 101319538
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - China
MH  - Cytokines/*blood
MH  - Immunity, Cellular/immunology
MH  - Molecular Sequence Data
MH  - Porcine Reproductive and Respiratory Syndrome/*immunology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Swine
MH  - Viral Load
OTO - NOTNLM
OT  - cytokines
OT  - highly pathogenic porcine reproductive and respiratory syndrome virus
OT  - immunity modulation
OT  - porcine reproductive and respiratory syndrome virus
EDAT- 2013/12/07 06:00
MHDA- 2016/04/28 06:00
CRDT- 2013/12/07 06:00
PHST- 2013/06/26 00:00 [received]
PHST- 2013/12/07 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2016/04/28 06:00 [medline]
AID - 10.1111/tbed.12190 [doi]
PST - ppublish
SO  - Transbound Emerg Dis. 2015 Oct;62(5):e1-e10. doi: 10.1111/tbed.12190. Epub 2013 
      Dec 6.