PMID- 24308748
OWN - NLM
STAT- MEDLINE
DCOM- 20150109
LR  - 20221207
IS  - 1557-9077 (Electronic)
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 24
IP  - 5
DP  - 2014 May
TI  - Association of HLA-B*51:01 with papillary thyroid carcinoma in the Chinese Han 
      population of the Shandong coastal areas.
PG  - 867-71
LID - 10.1089/thy.2013.0130 [doi]
AB  - BACKGROUND: A lot of work has been done to study the association between human 
      leukocyte antigen (HLA) and papillary thyroid carcinoma (PTC) in various 
      populations. But the results of the currently available studies are not 
      consistent. The aim of this study was to evaluate the association of HLA-A, -B, 
      -C, -DRB1, and -DQB1 with PTC in the Chinese Han population of the coastal areas 
      of Shandong Province with respect to age and sex. METHODS: A total of 154 
      patients diagnosed with PTC were analyzed for HLA-A, -B, -C, -DRB1, and -DQB1 
      alleles by using a polymerase chain reaction sequence-based typing (PCR-SBT) 
      method. Two hundred unrelated healthy individuals were typed as controls. 
      RESULTS: Compared with the controls, the HLA-B*51:01 (8.8% vs. 4.5%, p=0.029, OR 
      2.039 [CI 1.101-3.775]) and HLA-C*07:06 (2.6% vs. 0.5%, p=0.024, OR 5.307 [CI 
      1.119-25.171]) allele frequencies were higher in the PTC patients, while the 
      HLA-C*07:01 (1.3% vs. 6.0%, p=0.001, OR 0.206 [CI 0.071-0.601]) allele frequency 
      was lower in the PTC patients that did not persist after Bonferroni correction 
      for multiple tests. This showed no statistically significant correlation of the 
      HLA-A, -DRB1, and -DQB1 alleles and PTC. The incidence of PTC was more frequent 
      in females between 30 and 60 years old. There were no significant differences in 
      the age and sex distributions between the total and the HLA-B*51:01 positive PTC 
      patients. CONCLUSIONS: The HLA associations in this Chinese Han population differ 
      markedly from studies done in Europeans and Caucasians. The results reveal that 
      HLA-B*51:01 is more likely to be a susceptible allele for PTC in addition to age 
      and sex in the coastal areas of Shandong Province.
FAU - Shuxian, Jiao
AU  - Shuxian J
AD  - HLA Typing Lab, Institute of Transfusion Medicine , Qingdao Blood Center, 
      Qingdao, China .
FAU - Xiaoyun, Chi
AU  - Xiaoyun C
FAU - Zhihui, Feng
AU  - Zhihui F
FAU - Xiaohua, Liu
AU  - Xiaohua L
FAU - Zhanhui, Du
AU  - Zhanhui D
FAU - Bin, Hu
AU  - Bin H
FAU - Lin, Zhao
AU  - Lin Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140130
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B51 Antigen)
RN  - 0 (HLA-C Antigens)
SB  - IM
EIN - Thyroid. 2014 Sep;24(9):1437
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Asian People
MH  - Carcinoma/*genetics/metabolism
MH  - Carcinoma, Papillary
MH  - China
MH  - Cohort Studies
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-B Antigens/*genetics/metabolism
MH  - HLA-B51 Antigen/*genetics/metabolism
MH  - HLA-C Antigens/*genetics/metabolism
MH  - Hospitals, University
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Sex Characteristics
MH  - Thyroid Cancer, Papillary
MH  - Thyroid Neoplasms/*genetics/metabolism
MH  - Young Adult
PMC - PMC4026373
EDAT- 2013/12/07 06:00
MHDA- 2015/01/13 06:00
PMCR- 2015/05/01
CRDT- 2013/12/07 06:00
PHST- 2013/12/07 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2015/01/13 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - 10.1089/thy.2013.0130 [pii]
AID - 10.1089/thy.2013.0130 [doi]
PST - ppublish
SO  - Thyroid. 2014 May;24(5):867-71. doi: 10.1089/thy.2013.0130. Epub 2014 Jan 30.