PMID- 24308892
OWN - NLM
STAT- MEDLINE
DCOM- 20150706
LR  - 20131206
IS  - 1871-403X (Print)
IS  - 1871-403X (Linking)
VI  - 7
IP  - 6
DP  - 2013 Dec
TI  - Predictors of remission of type 2 diabetes mellitus in obese patients after 
      gastrointestinal surgery.
PG  - e494-500
LID - S1871-403X(12)00234-7 [pii]
LID - 10.1016/j.orcp.2012.08.190 [doi]
AB  - BACKGROUND: Gastroenterology is a beneficial treatment of morbidly obese type 2 
      diabetes mellitus (T2DM). We aimed to identify the predictors for the treatment 
      of T2DM obese patients. METHODS: A retrospective study consisting of 531 patients 
      undergoing laparoscopic gastric banding (LGB), laparoscopic mini-gastric bypass 
      (LMGB) and laparoscopic sleeve gastrectomy (LSG) from January 2004 to May 2007 
      was performed. Patients with preoperative fasting serum glucose concentration of 
      more than 126 mg/dl were diagnosed as T2DM. A postoperatively fasting serum 
      glucose level of less than 110 mg/dl was considered to be remission of T2DM. 
      RESULTS: Of the 531 patients, 62 (11.6%) were diagnosed as T2DM, including 23 men 
      and 39 women, with a mean age of 31.8 +/- 9.2 years, and a mean body mass index 
      (BMI) of 40.0 kg/m(2). The mean glucose at 3, 6, and 12 months after surgery were 
      100.1 mg/dl, 95.1 mg/dl and 91.8 mg/dl, respectively. The mean body weight loss 
      one year after surgery was 9.4% for LGB, 31.4% for LSG and 37.1% for LMGB, 
      respectively. Among these operation methods (LGB, LMGB and LSG), the BMI, body 
      weight, waist circumference, serum lipid profile and serum factors associated 
      with glucose metabolism were significantly different during the one-year 
      postoperative follow-up. Remission rate of T2DM was achieved in 84.8%, 58.8% and 
      58.3% of patients for LMGB, LGB and LSG, respectively. The best operative method 
      for the remission of T2DM was LMGB. Using an artificial neural network (ANN) data 
      mining technique, waist circumference, operative methods and C-peptide were 
      significantly predictors for the remission of T2 DM. CONCLUSION: One year after 
      gastrointestinal surgery, improvement of serum lipid profiles and serum data 
      related to glucose metabolism in the different operative methods were noticed. 
      LMGB seems to be the most effective procedure for the reduction of serum glucose 
      levels compared with LAGB and LSG.
CI  - A(c) 2013 Asian Oceanian Association for the Study of Obesity . Published by 
      Elsevier Ltd. All rights reserved.
FAU - Lee, Yi-Chih
AU  - Lee YC
AD  - Department of Surgery, Min-Sheng General Hospital, Taoyuan Hsien, Taiwan.
FAU - Lee, Wei-Jei
AU  - Lee WJ
FAU - Liew, Phui-Ly
AU  - Liew PL
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Obes Res Clin Pract
JT  - Obesity research & clinical practice
JID - 101303911
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Diabetes Mellitus, Type 2/blood/etiology/*surgery
MH  - Female
MH  - *Gastric Bypass
MH  - *Gastroplasty
MH  - Humans
MH  - *Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Obesity, Morbid/blood/complications/*surgery
MH  - Remission Induction
MH  - Retrospective Studies
MH  - Weight Loss
EDAT- 2013/12/07 06:00
MHDA- 2015/07/07 06:00
CRDT- 2013/12/07 06:00
PHST- 2011/09/28 00:00 [received]
PHST- 2012/08/01 00:00 [revised]
PHST- 2012/08/11 00:00 [accepted]
PHST- 2013/12/07 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2015/07/07 06:00 [medline]
AID - S1871-403X(12)00234-7 [pii]
AID - 10.1016/j.orcp.2012.08.190 [doi]
PST - ppublish
SO  - Obes Res Clin Pract. 2013 Dec;7(6):e494-500. doi: 10.1016/j.orcp.2012.08.190.