PMID- 24309215
OWN - NLM
STAT- MEDLINE
DCOM- 20141118
LR  - 20151119
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 28
IP  - 2
DP  - 2014 Mar-Apr
TI  - Quantitative imaging biomarkers for the evaluation of cardiovascular 
      complications in type 2 diabetes mellitus.
PG  - 234-42
LID - S1056-8727(13)00211-0 [pii]
LID - 10.1016/j.jdiacomp.2013.09.008 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a prevalent condition in aged populations. 
      Cardiovascular diseases are leading causes of death and disability in patients 
      with T2DM. Traditional strategies for controlling the cardiovascular 
      complications of diabetes primarily target a cluster of well-defined risk 
      factors, such as hyperglycemia, lipid disorders and hypertension. However, there 
      is controversy over some recent clinical trials aimed at evaluating efficacy of 
      intensive treatments for T2DM. As a powerful tool for quantitative cardiovascular 
      risk estimation, multi-disciplinary cardiovascular imaging have been applied to 
      detect and quantify morphological and functional abnormalities in the 
      cardiovascular system. Quantitative imaging biomarkers acquired with advanced 
      imaging procedures are expected to provide new insights to stratify absolute 
      cardiovascular risks and reduce the overall costs of health care for people with 
      T2DM by facilitating the selection of optimal therapies. This review discusses 
      principles of state-of-the-art cardiovascular imaging techniques and compares 
      applications of those techniques in various clinical circumstances. Individuals 
      measurements of cardiovascular disease burdens from multiple aspects, which are 
      closely related to existing biomarkers and clinical outcomes, are recommended as 
      promising candidates for quantitative imaging biomarkers to assess the responses 
      of the cardiovascular system during diabetic regimens.
CI  - (c) 2013 Elsevier Inc. All rights reserved.
FAU - Lin, Kai
AU  - Lin K
AD  - Department of Radiology, Northwestern University Feinberg School of Medicine, 
      737N Michigan Avenue, Suite 1600, Chicago, IL 60611, USA.
FAU - Lloyd-Jones, Donald M
AU  - Lloyd-Jones DM
AD  - Department of Preventive Medicine, Northwestern University Feinberg School of 
      Medicine, 680N Lake shore drive, Suite 1400, Chicago, IL 60611, USA.
FAU - Li, Debiao
AU  - Li D
AD  - Department of Radiology, Northwestern University Feinberg School of Medicine, 
      737N Michigan Avenue, Suite 1600, Chicago, IL 60611, USA.
FAU - Carr, James C
AU  - Carr JC
AD  - Department of Radiology, Northwestern University Feinberg School of Medicine, 
      737N Michigan Avenue, Suite 1600, Chicago, IL 60611, USA. Electronic address: 
      jcarr@northwestern.edu.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20131014
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/*analysis
MH  - Cardiovascular Diseases/diagnosis/etiology
MH  - Diabetes Mellitus, Type 2/*complications/*diagnosis
MH  - Diabetic Angiopathies/*diagnosis
MH  - Diabetic Nephropathies/diagnosis/etiology
MH  - Diagnostic Imaging/*methods
MH  - Humans
OTO - NOTNLM
OT  - Cardiovascular complications
OT  - Imaging biomarkers
OT  - T2DM
EDAT- 2013/12/07 06:00
MHDA- 2014/11/19 06:00
CRDT- 2013/12/07 06:00
PHST- 2013/05/09 00:00 [received]
PHST- 2013/09/19 00:00 [revised]
PHST- 2013/09/19 00:00 [accepted]
PHST- 2013/12/07 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2014/11/19 06:00 [medline]
AID - S1056-8727(13)00211-0 [pii]
AID - 10.1016/j.jdiacomp.2013.09.008 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2014 Mar-Apr;28(2):234-42. doi: 
      10.1016/j.jdiacomp.2013.09.008. Epub 2013 Oct 14.