PMID- 2430930
OWN - NLM
STAT- MEDLINE
DCOM- 19861229
LR  - 20171213
IS  - 8750-7587 (Print)
IS  - 0161-7567 (Linking)
VI  - 61
IP  - 4
DP  - 1986 Oct
TI  - Immunologic and nonimmunologic responsiveness in ragweed-sensitized dogs.
PG  - 1467-74
AB  - The relationship between airway responsiveness to inhaled antigen and histamine, 
      immunologic release of lung histamine, immunologic responsiveness of skin, and 
      specific immunoglobulin E (IgE) antibodies were examined in 11 inbred allergic 
      dogs immunized with extracts of ragweed and grass and 5 nonimmunized control dogs 
      from the same colony. Airway responsiveness to antigen and histamine was 
      characterized by the doses that increased the airflow resistance of the total 
      respiratory system to twice the control values (ED200). Highly significant 
      correlations were found between airway responsiveness and cutaneous 
      responsiveness to antigen and other immunologic characteristics (e.g., IgE and 
      histamine released from lung by inhaled antigen) in all dogs. In 
      ragweed-sensitized dogs, there was an inverse correlation between immunologic 
      responsiveness (reflected by the cutaneous response to antigen and histamine 
      released from lung by inhaled antigen) and nonimmunologic responsiveness of 
      airways (histamine ED200: r = 0.73, P less than 0.05 and r = 0.75, P less than 
      0.01, respectively). Antigen ED200 was also correlated with histamine release 
      from lung after antigen inhalation (r = 0.74; P less than 0.01). We conclude that 
      airway reactions to inhaled antigen in allergic dogs are dependent not only on 
      immunologic factors but also on the degree of nonimmunologic airway 
      responsiveness to histamine and that these factors are correlated inversely.
FAU - Mapp, C
AU  - Mapp C
FAU - Hartiala, J
AU  - Hartiala J
FAU - Frick, O L
AU  - Frick OL
FAU - Shields, R L
AU  - Shields RL
FAU - Gold, W M
AU  - Gold WM
LA  - eng
GR  - ES-01684-21/ES/NIEHS NIH HHS/United States
GR  - HL-24136/HL/NHLBI NIH HHS/United States
GR  - R01-AI-15233/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Appl Physiol (1985)
JT  - Journal of applied physiology (Bethesda, Md. : 1985)
JID - 8502536
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - *Antibody Formation
MH  - Dogs
MH  - Histamine/pharmacology
MH  - Histamine Release
MH  - *Immunization
MH  - Immunoglobulin E/analysis
MH  - Lung/physiology
MH  - Pollen/*immunology
MH  - Respiratory Function Tests
MH  - Skin Tests
EDAT- 1986/10/01 00:00
MHDA- 1986/10/01 00:01
CRDT- 1986/10/01 00:00
PHST- 1986/10/01 00:00 [pubmed]
PHST- 1986/10/01 00:01 [medline]
PHST- 1986/10/01 00:00 [entrez]
AID - 10.1152/jappl.1986.61.4.1467 [doi]
PST - ppublish
SO  - J Appl Physiol (1985). 1986 Oct;61(4):1467-74. doi: 10.1152/jappl.1986.61.4.1467.