PMID- 24310985
OWN - NLM
STAT- MEDLINE
DCOM- 20150226
LR  - 20140303
IS  - 1573-675X (Electronic)
IS  - 1360-8185 (Linking)
VI  - 19
IP  - 4
DP  - 2014 Apr
TI  - LIM homeobox transcription factor 1B is associated with pro-fibrotic components 
      and apoptosis in hypoxia/reoxygenation renal tubular epithelial cells.
PG  - 594-602
LID - 10.1007/s10495-013-0952-1 [doi]
AB  - LIM homeobox transcription factor 1B (LMX1B) is a transcription factor of the 
      LIM-homeodomain type, which plays an important role in foetal development during 
      formation of the extremities, kidneys, eyes, and the brain. Furthermore, LMX1B 
      has been implicated in nail-patella syndrome, which is predominantly 
      characterized by malformation of limbs and nails, and in 30 % of patients, 
      nephropathy, including renal fibrosis, is observed. Since no reports were 
      available that studied the link between LMX1B expression and pro-fibrotic 
      components and apoptosis in hypoxic renal tubular epithelial cells (RTEC), we 
      explored if LMX1B was associated with extracellular matrix components, 
      profibrotic factors, and apoptosis induced by hypoxia/reoxygenation (H-R). In 
      this cell system under hypoxic conditions, when the expression of LMX1B was 
      inhibited in H-R RTEC, the expression of transforming growth factor-betal, 
      collagen-III, fibronectin, cleaved caspase-3, and cell apoptosis rate was 
      increased. Consequently, overexpression of LMX1B was associated with reduced cell 
      apoptosis, whilst downregulation of LMX1B was associated with increased cell 
      apoptosis in H-R RTEC.
FAU - Zhou, Tian-Biao
AU  - Zhou TB
AD  - Department of Nephrology, The Sixth Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, 510655, China, a126tianbiao@126.com.
FAU - Xu, Hui-Ling
AU  - Xu HL
FAU - Qin, Yuan-Han
AU  - Qin YH
FAU - Lei, Feng-Ying
AU  - Lei FY
FAU - Huang, Wei-Fang
AU  - Huang WF
FAU - Drummen, Gregor P C
AU  - Drummen GP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Apoptosis
JT  - Apoptosis : an international journal on programmed cell death
JID - 9712129
RN  - 0 (LIM homeobox transcription factor 1 beta)
RN  - 0 (LIM-Homeodomain Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Cell Hypoxia
MH  - Cell Line
MH  - Epithelial Cells/metabolism/*pathology
MH  - Extracellular Matrix/*metabolism
MH  - Fibrosis
MH  - Kidney Tubules/metabolism/*pathology
MH  - LIM-Homeodomain Proteins/genetics/*metabolism
MH  - Oxidative Stress
MH  - Rats
MH  - Transcription Factors/genetics/*metabolism
EDAT- 2013/12/07 06:00
MHDA- 2015/02/27 06:00
CRDT- 2013/12/07 06:00
PHST- 2013/12/07 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2015/02/27 06:00 [medline]
AID - 10.1007/s10495-013-0952-1 [doi]
PST - ppublish
SO  - Apoptosis. 2014 Apr;19(4):594-602. doi: 10.1007/s10495-013-0952-1.