PMID- 24312122
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131206
LR  - 20211021
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 4
DP  - 2013
TI  - Identifying genetic predictors of depression risk: 5-HTTLPR and BDNF Val66Met 
      polymorphisms are associated with rumination and co-rumination in adolescents.
PG  - 246
LID - 10.3389/fgene.2013.00246 [doi]
LID - 246
AB  - BACKGROUND: Despite research supporting moderate heritability of depression, 
      efforts to replicate candidate gene associations to depression have yielded 
      inconsistent results. We tested whether Val66Met and 5-HTTLPR exhibit utility as 
      genetic markers of depression risk, testing for replicable associations to 
      cognitive and interpersonal endophenotypes of depression (rumination and 
      co-rumination), and further exploring developmental and sex moderation. METHOD: 
      In Study I, 228 youth (ages 8-14) of mothers with or without a history of MDD 
      during the child's lifetime were recruited from the community. Replication tests 
      were carried out in Study II, a sample of 87 youth with similar recruitment. 
      RESULTS: In Study I, the Val66Met single-nucleotide polymorphism (SNP) was 
      associated with rumination in adolescents, but not children, such that 
      adolescents homozygous for the Val allele reported higher rumination levels. 
      Further, a cumulative genetic score (CGS) (Val66Val and 5-HTTLPR) predicted 
      higher levels of co-rumination, specifically among adolescent girls. Both genetic 
      associations maintained significance after covarying for current depressive 
      symptomology, and the other endophenotype. Finally, both genetic associations 
      exhibited similar effect sizes in Study II, although results did not reach 
      statistical significance. CONCLUSIONS: RESULTS replicate a previously reported 
      association between the brain derived neurotrophic factor (BDNF) Val allele and 
      rumination in adolescents, and provide preliminary support for a CGS predictive 
      of co-rumination in adolescent girls. The current study indicates that candidate 
      genes may demonstrate utility as consistent genetic markers of depression risk 
      when focused on specific phenotypes, and supports the need to explore potential 
      differential effects of developmental stage and sex. However, given the small 
      sample sizes and possibility of chance findings, these results should be 
      interpreted with caution pending replication.
FAU - Stone, Lindsey B
AU  - Stone LB
AD  - Department of Psychiatry, Brown University Alpert Medical School Providence, RI, 
      USA ; Department of Psychology, Binghamton University Binghamton, NY, USA.
FAU - McGeary, John E
AU  - McGeary JE
FAU - Palmer, Rohan H C
AU  - Palmer RH
FAU - Gibb, Brandon E
AU  - Gibb BE
LA  - eng
GR  - K01 AA021113/AA/NIAAA NIH HHS/United States
GR  - R01 HD057066/HD/NICHD NIH HHS/United States
GR  - R03 HD048664/HD/NICHD NIH HHS/United States
GR  - S10 RR023457/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20131113
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC3826084
OTO - NOTNLM
OT  - 5-HTTLPR
OT  - BDNF Val66Met
OT  - co-rumination
OT  - depression
OT  - rumination
EDAT- 2013/12/07 06:00
MHDA- 2013/12/07 06:01
PMCR- 2013/11/13
CRDT- 2013/12/07 06:00
PHST- 2013/05/24 00:00 [received]
PHST- 2013/10/27 00:00 [accepted]
PHST- 2013/12/07 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2013/12/07 06:01 [medline]
PHST- 2013/11/13 00:00 [pmc-release]
AID - 10.3389/fgene.2013.00246 [doi]
PST - epublish
SO  - Front Genet. 2013 Nov 13;4:246. doi: 10.3389/fgene.2013.00246. eCollection 2013.