PMID- 24312130
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20211021
IS  - 1740-2530 (Electronic)
IS  - 1740-2522 (Print)
IS  - 1740-2522 (Linking)
VI  - 2013
DP  - 2013
TI  - Combination of human leukocyte antigen and killer cell immunoglobulin-like 
      receptor genetic background influences the onset age of hepatocellular carcinoma 
      in male patients with hepatitis B virus infection.
PG  - 874514
LID - 10.1155/2013/874514 [doi]
LID - 874514
AB  - To investigate whether killer cell immunoglobulin-like receptor (KIR) and human 
      leukocyte antigen (HLA) genetic background could influence the onset age of 
      hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV) 
      infection, one hundred and seventy-one males with HBV-related HCC were enrolled. 
      The presence of 12 loci of KIR was detected individually. HLA-A, -B, and -C loci 
      were genotyped with high resolution by a routine sequence-based typing method. 
      The effect of each KIR locus, HLA ligand, and HLA-KIR combination was examined 
      individually by Kaplan-Meier (KM) analysis. Multivariate Cox hazard regression 
      model was also applied. We identified C1C1-KIR2DS2/2DL2 as an independent risk 
      factor for earlier onset age of HCC (median onset age was 44 for 
      C1C1-KIR2DS2/2DL2 positive patients compared to 50 for negative patients, P = 
      0.04 for KM analysis; HR = 1.70, P = 0.004 for multivariate Cox model). We 
      conclude that KIR and HLA genetic background can influence the onset age of HCC 
      in male patients with HBV infection. This study may be useful to improve the 
      current HCC surveillance program in HBV-infected patients. Our findings also 
      suggest an important role of natural killer cells (or other KIR-expressing cells) 
      in the progress of HBV-related HCC development.
FAU - Pan, Ning
AU  - Pan N
AD  - Department of Pathogenic Biology and Immunology, Southeast University Medical 
      School, 87 Dingjiaqiao Road, Nanjing, Jiangsu 210009, China ; Key Laboratory of 
      Developmental Genes and Human Disease, Ministry of Education, Southeast 
      University, Nanjing, Jiangsu 210009, China.
FAU - Qiu, Jie
AU  - Qiu J
FAU - Sun, Hang
AU  - Sun H
FAU - Miao, Fengqin
AU  - Miao F
FAU - Shi, Qian
AU  - Shi Q
FAU - Xu, Jinhuan
AU  - Xu J
FAU - Jiang, Wei
AU  - Jiang W
FAU - Jin, Hui
AU  - Jin H
FAU - Xie, Wei
AU  - Xie W
FAU - He, Youji
AU  - He Y
FAU - Zhang, Jianqiong
AU  - Zhang J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131110
PL  - Egypt
TA  - Clin Dev Immunol
JT  - Clinical & developmental immunology
JID - 101183692
RN  - 0 (HLA Antigens)
RN  - 0 (Ligands)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Alleles
MH  - Carcinoma, Hepatocellular/*etiology/metabolism/mortality
MH  - Genotype
MH  - HLA Antigens/*genetics/immunology/metabolism
MH  - Hepatitis B/*complications
MH  - *Hepatitis B virus
MH  - Humans
MH  - Ligands
MH  - Liver Neoplasms/*etiology/metabolism/mortality
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Receptors, KIR/*genetics
MH  - Sex Factors
PMC - PMC3842051
EDAT- 2013/12/07 06:00
MHDA- 2014/06/10 06:00
PMCR- 2013/11/10
CRDT- 2013/12/07 06:00
PHST- 2013/07/15 00:00 [received]
PHST- 2013/09/17 00:00 [revised]
PHST- 2013/09/17 00:00 [accepted]
PHST- 2013/12/07 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
PHST- 2013/11/10 00:00 [pmc-release]
AID - 10.1155/2013/874514 [doi]
PST - ppublish
SO  - Clin Dev Immunol. 2013;2013:874514. doi: 10.1155/2013/874514. Epub 2013 Nov 10.