PMID- 24312131
OWN - NLM
STAT- MEDLINE
DCOM- 20140609
LR  - 20211021
IS  - 1740-2530 (Electronic)
IS  - 1740-2522 (Print)
IS  - 1740-2522 (Linking)
VI  - 2013
DP  - 2013
TI  - An elucidation of neutrophil functions against Mycobacterium tuberculosis 
      infection.
PG  - 959650
LID - 10.1155/2013/959650 [doi]
LID - 959650
AB  - We characterized the functions of neutrophils in response to Mycobacterium 
      tuberculosis (M. tb) infection, with particular reference to glutathione (GSH). 
      We examined the effects of GSH in improving the ability of neutrophils to control 
      intracellular M. tb infection. Our findings indicate that increasing the 
      intracellular levels of GSH with a liposomal formulation of GSH (L-GSH) resulted 
      in reduction in the levels of free radicals and increased acidification of M. tb 
      containing phagosomes leading to the inhibition in the growth of M. tb. This 
      inhibitory mechanism is dependent on the presence of TNF-alpha and IL-6. Our studies 
      demonstrate a novel regulatory mechanism adapted by the neutrophils to control M. 
      tb infection.
FAU - Morris, Devin
AU  - Morris D
AD  - College of Osteopathic Medicine of the Pacific, Western University of Health 
      Sciences, Pomona, CA 91766, USA.
FAU - Nguyen, Thien
AU  - Nguyen T
FAU - Kim, John
AU  - Kim J
FAU - Kassissa, Christine
AU  - Kassissa C
FAU - Khurasany, Melissa
AU  - Khurasany M
FAU - Luong, Jennifer
AU  - Luong J
FAU - Kasko, Sarah
AU  - Kasko S
FAU - Pandya, Shalin
AU  - Pandya S
FAU - Chu, Michael
AU  - Chu M
FAU - Chi, Po-Ting
AU  - Chi PT
FAU - Ly, Judy
AU  - Ly J
FAU - Lagman, Minette
AU  - Lagman M
FAU - Venketaraman, Vishwanath
AU  - Venketaraman V
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131107
PL  - Egypt
TA  - Clin Dev Immunol
JT  - Clinical & developmental immunology
JID - 101183692
RN  - 0 (Free Radicals)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - GAN16C9B8O (Glutathione)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/pharmacology
MH  - Free Radicals/metabolism
MH  - Glutathione/metabolism
MH  - Humans
MH  - Interleukin-6/biosynthesis
MH  - Mycobacterium tuberculosis/*immunology
MH  - Neutrophils/drug effects/*immunology/metabolism/*microbiology
MH  - Phagosomes/metabolism/microbiology
MH  - Tumor Necrosis Factor-alpha/biosynthesis
PMC - PMC3838815
EDAT- 2013/12/07 06:00
MHDA- 2014/06/10 06:00
PMCR- 2013/11/07
CRDT- 2013/12/07 06:00
PHST- 2013/08/28 00:00 [received]
PHST- 2013/10/01 00:00 [accepted]
PHST- 2013/12/07 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2014/06/10 06:00 [medline]
PHST- 2013/11/07 00:00 [pmc-release]
AID - 10.1155/2013/959650 [doi]
PST - ppublish
SO  - Clin Dev Immunol. 2013;2013:959650. doi: 10.1155/2013/959650. Epub 2013 Nov 7.