PMID- 24312875
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20131206
LR  - 20211021
IS  - 2228-5881 (Print)
IS  - 2251-7308 (Electronic)
IS  - 2228-5881 (Linking)
VI  - 3
IP  - 2
DP  - 2013
TI  - HLA-G Expression Pattern: Reliable Assessment for Pregnancy Outcome Prediction.
PG  - 443-6
LID - 10.5681/apb.2013.072 [doi]
AB  - Because mothers and fathers are more or less dissimilar at multiple HLA loci, 
      mother considers her fetus as a semi-allograft. Mother's immune system may 
      recognize paternal HLA as foreign antigen and may develop anti-paternal HLA 
      antibodies and cytotoxic T lymphocyte. There are some mechanisms that modulate 
      maternal immune responses during pregnancy, in order to make uterus an immune 
      privileged site. This immunosuppression is believed to be mediated, at least 
      partly, by HLA-G, non-classical class I human leukocyte antigen (HLA) molecule 
      that is strongly expressed in cytotrophoblast and placenta. The major HLA-G 
      function is its ability to inhibit T and B lymphocytes, NK cells and 
      antigen-presenting cells (APC).Since HLA-G is expressed strongly at the 
      maternofetal interface and has an essential role in immunosuppression, HLA-G 
      polymorphism and altered expression of HLA-G seems to be associated with some 
      complications of pregnancy, such as pre-eclampsia, recurrent misscariage and 
      failure in IVF.This perspective discusses recent findings about HLA-G genetics, 
      function, expression and polymorphism; and focus on HLA-G role in the etiology of 
      recurrent miscarriage.
FAU - Mosaferi, Elnaz
AU  - Mosaferi E
AD  - Immunology Research Center,Tabriz university of Medical Sciences. Tabriz. Iran. ; 
      Tabriz International University of Medical Sciences, Tabriz, Iran.
FAU - Majidi, Jafar
AU  - Majidi J
FAU - Mohammadian, Mojdeh
AU  - Mohammadian M
FAU - Babaloo, Zohreh
AU  - Babaloo Z
FAU - Monfaredan, Amir
AU  - Monfaredan A
FAU - Baradaran, Behzad
AU  - Baradaran B
LA  - eng
PT  - Journal Article
DEP - 20130820
PL  - Iran
TA  - Adv Pharm Bull
JT  - Advanced pharmaceutical bulletin
JID - 101578021
PMC - PMC3848239
OTO - NOTNLM
OT  - HLA-G
OT  - Placenta
OT  - Recurrent miscarriage
EDAT- 2013/12/07 06:00
MHDA- 2013/12/07 06:01
PMCR- 2013/12/01
CRDT- 2013/12/07 06:00
PHST- 2013/04/12 00:00 [received]
PHST- 2013/05/16 00:00 [revised]
PHST- 2013/05/18 00:00 [accepted]
PHST- 2013/12/07 06:00 [entrez]
PHST- 2013/12/07 06:00 [pubmed]
PHST- 2013/12/07 06:01 [medline]
PHST- 2013/12/01 00:00 [pmc-release]
AID - 10.5681/apb.2013.072 [doi]
PST - ppublish
SO  - Adv Pharm Bull. 2013;3(2):443-6. doi: 10.5681/apb.2013.072. Epub 2013 Aug 20.