PMID- 24314294
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140107
LR  - 20211021
IS  - 2045-3701 (Print)
IS  - 2045-3701 (Electronic)
IS  - 2045-3701 (Linking)
VI  - 3
IP  - 1
DP  - 2013 Dec 6
TI  - Bone marrow-derived stem cells ameliorate hepatic fibrosis by down-regulating 
      interleukin-17.
PG  - 46
LID - 10.1186/2045-3701-3-46 [doi]
AB  - BACKGROUND: Accumulating evidences have identified the immunoregulatory features 
      of stem cells. In this study, the immunoregulation of bone marrow-derived stem 
      cells (BMSCs) transplanted into patients with HBV-related decompensated cirrhosis 
      and mouse model of liver injury induced by carbon tetrachloride (CCl4) 
      administration was observed. RESULTS: Compared with healthy controls, patients 
      with HBV-related decompensated cirrhosis showed significantly higher levels of 
      TNF-alpha, IL-12, TGF-beta1, IL-17, and IL-8. However, only IL-17 was markedly 
      decreased after autologous BMSCs transplantation during their follow-up. The same 
      results were found in the CCl4-treated mice. Furthermore, we found that exogenous 
      IL-17 partly abolished the therapeutic effect of BMSCs whereas IL-17-specific 
      antibody promoted improvement of liver injury in CCl4-treated mice, resembling 
      the therapeutic effect of BMSCs transplantation. CONCLUSIONS: These data 
      suggested that BMSCs transplantation induces a decrease of IL-17 level, which at 
      least in part delineates the mechanisms of stem cells-mediated therapeutic 
      benefit on liver disease.
FAU - Zheng, Linhua
AU  - Zheng L
AD  - State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Disease, 
      Xijing Hospital, Fourth Military Medical University, 127 Changle Western Road, 
      Xi'an 710032, Shaanxi Province, China.
FAU - Chu, Jindong
AU  - Chu J
AD  - State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Disease, 
      Xijing Hospital, Fourth Military Medical University, 127 Changle Western Road, 
      Xi'an 710032, Shaanxi Province, China.
FAU - Shi, Yongquan
AU  - Shi Y
AD  - State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Disease, 
      Xijing Hospital, Fourth Military Medical University, 127 Changle Western Road, 
      Xi'an 710032, Shaanxi Province, China.
FAU - Zhou, Xinmin
AU  - Zhou X
AD  - State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Disease, 
      Xijing Hospital, Fourth Military Medical University, 127 Changle Western Road, 
      Xi'an 710032, Shaanxi Province, China.
FAU - Tan, Ling
AU  - Tan L
AD  - Department of Pediatric Dentistry, School of Stomatology, Fourth Military Medical 
      University, Xi'an 710032, China.
FAU - Li, Qiang
AU  - Li Q
AD  - State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Disease, 
      Xijing Hospital, Fourth Military Medical University, 127 Changle Western Road, 
      Xi'an 710032, Shaanxi Province, China.
FAU - Cui, Lina
AU  - Cui L
AD  - State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Disease, 
      Xijing Hospital, Fourth Military Medical University, 127 Changle Western Road, 
      Xi'an 710032, Shaanxi Province, China.
FAU - Han, Zheyi
AU  - Han Z
AD  - State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Disease, 
      Xijing Hospital, Fourth Military Medical University, 127 Changle Western Road, 
      Xi'an 710032, Shaanxi Province, China.
FAU - Han, Ying
AU  - Han Y
AD  - State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Disease, 
      Xijing Hospital, Fourth Military Medical University, 127 Changle Western Road, 
      Xi'an 710032, Shaanxi Province, China.
FAU - Fan, Daiming
AU  - Fan D
AD  - State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Disease, 
      Xijing Hospital, Fourth Military Medical University, 127 Changle Western Road, 
      Xi'an 710032, Shaanxi Province, China.
LA  - eng
PT  - Journal Article
DEP - 20131206
PL  - England
TA  - Cell Biosci
JT  - Cell & bioscience
JID - 101561195
PMC - PMC3882099
EDAT- 2013/12/10 06:00
MHDA- 2013/12/10 06:01
PMCR- 2013/12/06
CRDT- 2013/12/10 06:00
PHST- 2013/08/03 00:00 [received]
PHST- 2013/10/28 00:00 [accepted]
PHST- 2013/12/10 06:00 [entrez]
PHST- 2013/12/10 06:00 [pubmed]
PHST- 2013/12/10 06:01 [medline]
PHST- 2013/12/06 00:00 [pmc-release]
AID - 2045-3701-3-46 [pii]
AID - 10.1186/2045-3701-3-46 [doi]
PST - epublish
SO  - Cell Biosci. 2013 Dec 6;3(1):46. doi: 10.1186/2045-3701-3-46.