PMID- 24314536
OWN - NLM
STAT- MEDLINE
DCOM- 20140905
LR  - 20220331
IS  - 1872-6283 (Electronic)
IS  - 0379-0738 (Linking)
VI  - 233
IP  - 1-3
DP  - 2013 Dec 10
TI  - Analysis of UR-144 and its pyrolysis product in blood and their metabolites in 
      urine.
PG  - 320-7
LID - S0379-0738(13)00450-7 [pii]
LID - 10.1016/j.forsciint.2013.10.005 [doi]
AB  - UR-144 [(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone] is a 
      synthetic cannabinoid, which has been detected in many herbal blends, resinous 
      samples and powders seized from the Polish drug market since the beginning of 
      2012. This paper presents the case of intoxication by this substance. A complete 
      picture of the symptoms observed by a witness, paramedics and medical doctors are 
      given. In the analysis of powder residues from the plastic bag seized from the 
      intoxicated person by gas chromatography-mass spectrometry (GC-MS), UR-144 and 
      its major pyrolysis product 
      [1-(1-pentyl-1H-indol-3-yl)-3-methyl-2-(propan-2-yl)but-3-en-1-one] were 
      detected. Both substances were also identified in a blood sample collected on 
      admission of the patient to hospital using liquid chromatography-triple 
      quadrupole tandem mass spectrometry (LC-QqQ-MS). Blood concentration of UR-144 
      was 6.1 ng/mL. A urine sample collected at the same time was analyzed by liquid 
      chromatography-quadruple time-of-flight tandem mass spectrometry (LC-QTOF-MS). 
      The parent substance and its pyrolysis products were not detected in urine, while 
      their five metabolites were found. The experiments allowed the location of 
      derivative groups to be established, and thus elucidate rough structures of the 
      metabolites; a dihydroxylated metabolite of UR-144 and mono-, dihydroxylated and 
      carboxylated metabolites of its pyrolysis product were identified.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Adamowicz, Piotr
AU  - Adamowicz P
AD  - Institute of Forensic Research, Westerplatte 9, 31-033 Krakow, Poland. Electronic 
      address: padamowicz@ies.krakow.pl.
FAU - Zuba, Dariusz
AU  - Zuba D
FAU - Sekula, Karolina
AU  - Sekula K
LA  - eng
PT  - Journal Article
DEP - 20131014
PL  - Ireland
TA  - Forensic Sci Int
JT  - Forensic science international
JID - 7902034
RN  - 0 ((1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone)
RN  - 0 (Cannabinoids)
RN  - 0 (Illicit Drugs)
RN  - 0 (Indoles)
RN  - 0 (Powders)
SB  - IM
MH  - Cannabinoids/*blood/*urine
MH  - Chromatography, Liquid
MH  - Forensic Toxicology
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Illicit Drugs/blood/urine
MH  - Indoles/*blood/*urine
MH  - Male
MH  - Powders/chemistry
MH  - Reproducibility of Results
MH  - Substance Abuse Detection
MH  - Tandem Mass Spectrometry
MH  - Young Adult
OTO - NOTNLM
OT  - Analysis
OT  - Intoxication
OT  - LC-MS/MS
OT  - Synthetic cannabinoids
OT  - UR-144
EDAT- 2013/12/10 06:00
MHDA- 2014/09/06 06:00
CRDT- 2013/12/10 06:00
PHST- 2013/06/14 00:00 [received]
PHST- 2013/09/17 00:00 [revised]
PHST- 2013/10/05 00:00 [accepted]
PHST- 2013/12/10 06:00 [entrez]
PHST- 2013/12/10 06:00 [pubmed]
PHST- 2014/09/06 06:00 [medline]
AID - S0379-0738(13)00450-7 [pii]
AID - 10.1016/j.forsciint.2013.10.005 [doi]
PST - ppublish
SO  - Forensic Sci Int. 2013 Dec 10;233(1-3):320-7. doi: 
      10.1016/j.forsciint.2013.10.005. Epub 2013 Oct 14.