PMID- 24315025
OWN - NLM
STAT- MEDLINE
DCOM- 20141107
LR  - 20221207
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 487
DP  - 2014 Jul 15
TI  - Ozonation of wastewater: removal and transformation products of drugs of abuse.
PG  - 763-70
LID - S0048-9697(13)01297-7 [pii]
LID - 10.1016/j.scitotenv.2013.11.023 [doi]
AB  - In this study amphetamine, methamphetamine, methylenedioxymethamphetamine (MDMA), 
      cocaine (COC), benzoylecgonine (BE), ketamine (KET) and oxycodone (OXY) in 
      wastewater at concentrations of 100 mugL(-1) were subjected to ozone to determine 
      their removals as a function of ozone dose and to identify significant oxidation 
      transformation products (OTPs) produced as a result of ozonation. A method based 
      on high resolution mass spectrometry and differential analysis was used to 
      facilitate and accelerate the identification and structural elucidation of the 
      transformation products. The drug removal ranged from 3 to 50% depending on the 
      complexity of the matrix and whether a mixture or individual drugs were ozonated. 
      Both transient and persistent oxidation transformation products were identified 
      for MDMA, COC and OXY and their chemical formulae were determined. Three possible 
      structures of the persistent transformation product of MDMA (OTP-213) with 
      chemical formula C10H16O4N, were determined based on MS(n) mass spectra and the 
      most plausible structure (OTP-213a) was determined based on the chemistry of 
      ozone. These results indicate that ozone is capable of removing drugs of abuse 
      from wastewater to varying extents and that persistent transformation products 
      are produced as a result of treatment.
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Rodayan, Angela
AU  - Rodayan A
AD  - Department of Chemical Engineering, McGill University, 3610 University Street, 
      Montreal, Quebec, Canada, H3A 2B2.
FAU - Segura, Pedro Alejandro
AU  - Segura PA
AD  - Department of Chemical Engineering, McGill University, 3610 University Street, 
      Montreal, Quebec, Canada, H3A 2B2.
FAU - Yargeau, Viviane
AU  - Yargeau V
AD  - Department of Chemical Engineering, McGill University, 3610 University Street, 
      Montreal, Quebec, Canada, H3A 2B2. Electronic address: viviane.yargeau@mcgill.ca.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131207
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Illicit Drugs)
RN  - 0 (Waste Water)
RN  - 0 (Water Pollutants, Chemical)
RN  - 66H7ZZK23N (Ozone)
SB  - IM
MH  - Illicit Drugs/analysis/*chemistry
MH  - Ozone/*chemistry
MH  - Waste Disposal, Fluid/*methods
MH  - Wastewater/*chemistry
MH  - Water Pollutants, Chemical/*chemistry
OTO - NOTNLM
OT  - Amphetamines
OT  - Cocaine
OT  - Drugs of abuse
OT  - High resolution mass spectrometry
OT  - Ozone
OT  - Wastewater
EDAT- 2013/12/10 06:00
MHDA- 2014/11/08 06:00
CRDT- 2013/12/10 06:00
PHST- 2013/07/30 00:00 [received]
PHST- 2013/10/18 00:00 [revised]
PHST- 2013/11/04 00:00 [accepted]
PHST- 2013/12/10 06:00 [entrez]
PHST- 2013/12/10 06:00 [pubmed]
PHST- 2014/11/08 06:00 [medline]
AID - S0048-9697(13)01297-7 [pii]
AID - 10.1016/j.scitotenv.2013.11.023 [doi]
PST - ppublish
SO  - Sci Total Environ. 2014 Jul 15;487:763-70. doi: 10.1016/j.scitotenv.2013.11.023. 
      Epub 2013 Dec 7.