PMID- 24315973
OWN - NLM
STAT- MEDLINE
DCOM- 20140909
LR  - 20140113
IS  - 1873-5894 (Electronic)
IS  - 0730-725X (Linking)
VI  - 32
IP  - 2
DP  - 2014 Feb
TI  - Distribution of late gadolinium enhancement in end-stage hypertrophic 
      cardiomyopathy and dilated cardiomyopathy: differential diagnosis and prediction 
      of cardiac outcome.
PG  - 118-24
LID - S0730-725X(13)00339-1 [pii]
LID - 10.1016/j.mri.2013.10.011 [doi]
AB  - BACKGROUND: The prognostic implications of late gadolinium enhancement (LGE) have 
      been evaluated in ischemic and non-ischemic cardiomyopathies. The present study 
      analyzed LGE distribution in patients with end-stage hypertrophic cardiomyopathy 
      (ES-HCM) and with dilated cardiomyopathy (DCM), and tried to identify high risk 
      patients in DCM. METHODS: Eleven patients with ES-HCM and 72 with DCM underwent 
      cine- and LGE-cardiac magnetic resonance and ultrasound cardiography. The patient 
      outcome was analyzed retrospectively for 5years of follow-up. RESULTS: LGE 
      distributed mainly in the inter-ventricular septum, but spread more diffusely 
      into other left ventricular segments in patients with ES-HCM and in a certain 
      part of patients with DCM. Thus, patients with DCM can be divided into three 
      groups according to LGE distribution; no LGE (n=24), localized LGE (localized at 
      septum, n=36), and extensive LGE (spread into other segments, n=12). Reverse 
      remodeling occurred after treatment in patients with no LGE and with localized 
      LGE, but did not in patients with extensive LGE and with ES-HCM. The event-free 
      survival rate for composite outcome (cardiac death, hospitalization for 
      decompensated heart failure or ventricular arrhythmias) was lowest in patients 
      with extensive LGE (92%, 74% and 42% in no LGE, localized LGE, and extensive LGE, 
      p=0.02 vs. no LGE), and was comparable to that in patients with ES-HCM (42%). 
      CONCLUSIONS: In DCM, patients with extensive LGE showed no functional recovery 
      and the lowest event-free survival rate that were comparable to patients with 
      ES-HCM. The analysis of LGE distribution may be valuable to predict reverse 
      remodeling and to identify high-risk patients.
CI  - (c) 2013.
FAU - Machii, Masashi
AU  - Machii M
AD  - Division of Cardiology, Internal Medicine III, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Satoh, Hiroshi
AU  - Satoh H
AD  - Division of Cardiology, Internal Medicine III, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan. Electronic address: satoh36@hama-med.ac.jp.
FAU - Shiraki, Katsunori
AU  - Shiraki K
AD  - Division of Cardiology, Internal Medicine III, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Saotome, Masao
AU  - Saotome M
AD  - Division of Cardiology, Internal Medicine III, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Urushida, Tsuyoshi
AU  - Urushida T
AD  - Division of Cardiology, Internal Medicine III, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Katoh, Hideki
AU  - Katoh H
AD  - Division of Cardiology, Internal Medicine III, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
FAU - Takehara, Yasuo
AU  - Takehara Y
AD  - Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, 
      Japan.
FAU - Sakahara, Harumi
AU  - Sakahara H
AD  - Department of Radiology, Hamamatsu University School of Medicine, Hamamatsu, 
      Japan.
FAU - Ohtani, Hayato
AU  - Ohtani H
AD  - Department of Cardiology, Seirei Mikatahara General Hospital, Hamamatsu, Japan.
FAU - Wakabayashi, Yasushi
AU  - Wakabayashi Y
AD  - Department of Cardiology, Seirei Mikatahara General Hospital, Hamamatsu, Japan.
FAU - Ukigai, Hiroshi
AU  - Ukigai H
AD  - Department of Cardiology, Hamamatsu Red Cross Hospital, Hamamatsu, Japan.
FAU - Tawarahara, Kei
AU  - Tawarahara K
AD  - Department of Cardiology, Hamamatsu Red Cross Hospital, Hamamatsu, Japan.
FAU - Hayashi, Hideharu
AU  - Hayashi H
AD  - Division of Cardiology, Internal Medicine III, Hamamatsu University School of 
      Medicine, Hamamatsu, Japan.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20131022
PL  - Netherlands
TA  - Magn Reson Imaging
JT  - Magnetic resonance imaging
JID - 8214883
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Dilated/diagnosis/*pathology
MH  - Cardiomyopathy, Hypertrophic/diagnosis/*pathology
MH  - Contrast Media/chemistry
MH  - Diagnosis, Differential
MH  - Disease-Free Survival
MH  - Echocardiography, Doppler
MH  - Female
MH  - Follow-Up Studies
MH  - Gadolinium DTPA/*chemistry
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Retrospective Studies
MH  - Risk
MH  - Ultrasonography
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Dilated cardiomyopathy
OT  - End-stage hypertrophic cardiomyopathy
OT  - Late gadolinium enhancement
OT  - Outcomes
OT  - Reverse remodeling
EDAT- 2013/12/10 06:00
MHDA- 2014/09/10 06:00
CRDT- 2013/12/10 06:00
PHST- 2012/12/18 00:00 [received]
PHST- 2013/06/11 00:00 [revised]
PHST- 2013/10/11 00:00 [accepted]
PHST- 2013/12/10 06:00 [entrez]
PHST- 2013/12/10 06:00 [pubmed]
PHST- 2014/09/10 06:00 [medline]
AID - S0730-725X(13)00339-1 [pii]
AID - 10.1016/j.mri.2013.10.011 [doi]
PST - ppublish
SO  - Magn Reson Imaging. 2014 Feb;32(2):118-24. doi: 10.1016/j.mri.2013.10.011. Epub 
      2013 Oct 22.