PMID- 24316227
OWN - NLM
STAT- MEDLINE
DCOM- 20140227
LR  - 20131224
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Linking)
VI  - 588
IP  - 1
DP  - 2014 Jan 3
TI  - Trk receptors need neutral sphingomyelinase activity to promote cell viability.
PG  - 167-74
LID - S0014-5793(13)00876-4 [pii]
LID - 10.1016/j.febslet.2013.11.032 [doi]
AB  - Neurotrophins are a group of secreted polypeptides, which comprises Nerve Growth 
      Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). Each neurotrophin can 
      bind specifically to a tyrosine kinase Trk receptor (TrkA, TrkB or TrkC), while 
      all of the neurotrophins can bind, with similar affinity, to the p75 neurotrophin 
      receptor (p75(NTR)). Experiments on cell viability promotion by BDNF in granule 
      neurons or by NGF in PC12 cells show that neurotrophin-exerted cell viability is 
      neutral sphingomyelinase (nSMase)-dependent, since GW4869 or siRNA knockdown 
      abrogates the protective effects, as well as neurotrophin-induced Akt 
      phosphorylation. Finally, the assessment of nSMase activity promotion drives to 
      the conclusion that neurotrophins can promote cell viability through Trk 
      receptors in a manner depending on basal nSMase but not through SMase activity 
      enhancement.
CI  - Copyright (c) 2013 Federation of European Biochemical Societies. Published by 
      Elsevier B.V. All rights reserved.
FAU - Candalija, Ana
AU  - Candalija A
AD  - Department of Biochemistry and Molecular Biology, Institute of Neurosciences, 
      Universitat Autonoma de Barcelona, Cerdanyola del Valles, Catalunya, Spain.
FAU - Cubi, Roger
AU  - Cubi R
AD  - Department of Biochemistry and Molecular Biology, Institute of Neurosciences, 
      Universitat Autonoma de Barcelona, Cerdanyola del Valles, Catalunya, Spain.
FAU - Ortega, Arturo
AU  - Ortega A
AD  - Departamento de Genetica y Biologia Molecular, Cinvestav-IPN, Mexico DF, Mexico.
FAU - Aguilera, Jose
AU  - Aguilera J
AD  - Department of Biochemistry and Molecular Biology, Institute of Neurosciences, 
      Universitat Autonoma de Barcelona, Cerdanyola del Valles, Catalunya, Spain; 
      Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas 
      (CIBERNED), Spain. Electronic address: jose.aguilera@uab.cat.
FAU - Gil, Carles
AU  - Gil C
AD  - Department of Biochemistry and Molecular Biology, Institute of Neurosciences, 
      Universitat Autonoma de Barcelona, Cerdanyola del Valles, Catalunya, Spain. 
      Electronic address: carles.gil@uab.cat.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131205
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Aniline Compounds)
RN  - 0 (Benzylidene Compounds)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (GW 4869)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - EC 3.1.4.12 (Sphingomyelin Phosphodiesterase)
SB  - IM
MH  - Aniline Compounds/pharmacology
MH  - Animals
MH  - Apoptosis/drug effects
MH  - Benzylidene Compounds/pharmacology
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Cerebellum/cytology
MH  - Microscopy, Fluorescence
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - Nerve Growth Factor/pharmacology
MH  - Neurons/cytology/drug effects/*metabolism
MH  - PC12 Cells
MH  - Phosphorylation/drug effects
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - RNA Interference
MH  - Rats
MH  - Receptor, trkA/*metabolism
MH  - Receptor, trkB/*metabolism
MH  - Receptor, trkC/*metabolism
MH  - Sphingomyelin Phosphodiesterase/antagonists & inhibitors/genetics/*metabolism
OTO - NOTNLM
OT  - 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
OT  - BDNF
OT  - Brain-Derived Neurotrophic Factor
OT  - CGN
OT  - Cer
OT  - Ceramide
OT  - Granule neuron
OT  - MTT
OT  - NGF
OT  - NT
OT  - Nerve Growth Factor
OT  - Neurotrophin
OT  - PC12
OT  - Phosphorylation
OT  - SM
OT  - SphK
OT  - Sphingomyelinase
OT  - ceramide
OT  - cultured granule neurons
OT  - nSMase
OT  - neurotrophins
OT  - neutral sphingomyelinase
OT  - sphingomyelin
OT  - sphingosine kinase
EDAT- 2013/12/10 06:00
MHDA- 2014/02/28 06:00
CRDT- 2013/12/10 06:00
PHST- 2013/07/12 00:00 [received]
PHST- 2013/11/19 00:00 [revised]
PHST- 2013/11/25 00:00 [accepted]
PHST- 2013/12/10 06:00 [entrez]
PHST- 2013/12/10 06:00 [pubmed]
PHST- 2014/02/28 06:00 [medline]
AID - S0014-5793(13)00876-4 [pii]
AID - 10.1016/j.febslet.2013.11.032 [doi]
PST - ppublish
SO  - FEBS Lett. 2014 Jan 3;588(1):167-74. doi: 10.1016/j.febslet.2013.11.032. Epub 
      2013 Dec 5.