PMID- 24317073
OWN - NLM
STAT- MEDLINE
DCOM- 20140818
LR  - 20131224
IS  - 1347-6947 (Electronic)
IS  - 0916-8451 (Linking)
VI  - 77
IP  - 12
DP  - 2013
TI  - Lysophosphatidylcholine potentiates BDNF-induced TrkB phosphorylation and 
      downstream signals in cerebellar granule neurons.
PG  - 2510-3
AB  - We found that brain-derived neurotrophic factor (BDNF)-induced phosphorylation of 
      mitogen-activated protein kinase (MAPK) and Akt in cerebellar granule neurons was 
      specifically potentiated by LPC. LPC also augmented the BDNF-induced 
      phosphorylation of TrkB, the receptor for BDNF. In TrkB-transfected CHO-K1 cells, 
      LPC potentiated BDNF-induced MAPK phosphorylation. These results suggest that LPC 
      plays a role in BDNF-TrkB signaling by regulating the activation of TrkB.
FAU - Wuhanqimuge
AU  - Wuhanqimuge
AD  - Department of Biotechnology, The University of Tokyo.
FAU - Arioka, Manabu
AU  - Arioka M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131207
PL  - England
TA  - Biosci Biotechnol Biochem
JT  - Bioscience, biotechnology, and biochemistry
JID - 9205717
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lysophosphatidylcholines)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - CHO Cells
MH  - Cerebellum/*cytology
MH  - Cricetinae
MH  - Cricetulus
MH  - Humans
MH  - Lysophosphatidylcholines/*pharmacology
MH  - Mice
MH  - Neurons/*cytology/*drug effects
MH  - Phosphorylation/drug effects
MH  - Receptor, trkB/*metabolism
MH  - Signal Transduction/*drug effects
EDAT- 2013/12/10 06:00
MHDA- 2014/08/19 06:00
CRDT- 2013/12/10 06:00
PHST- 2013/12/10 06:00 [entrez]
PHST- 2013/12/10 06:00 [pubmed]
PHST- 2014/08/19 06:00 [medline]
AID - DN/JST.JSTAGE/bbb/130622 [pii]
AID - 10.1271/bbb.130622 [doi]
PST - ppublish
SO  - Biosci Biotechnol Biochem. 2013;77(12):2510-3. doi: 10.1271/bbb.130622. Epub 2013 
      Dec 7.