PMID- 24318406
OWN - NLM
STAT- MEDLINE
DCOM- 20140505
LR  - 20220409
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 75
IP  - 2
DP  - 2014 Feb
TI  - Herpes simplex virus encephalitis is a trigger of brain autoimmunity.
PG  - 317-23
LID - 10.1002/ana.24083 [doi]
AB  - In 5 prospectively diagnosed patients with relapsing post-herpes simplex 
      encephalitis (HSE), N-methyl-D-aspartate receptor (NMDAR) antibodies were 
      identified. Antibody synthesis started 1 to 4 weeks after HSE, preceding the 
      neurological relapse. Three of 5 patients improved postimmunotherapy, 1 
      spontaneously, and 1 has started to improve. Two additional patients with NMDAR 
      antibodies, 9 with unknown neuronal surface antibodies, and 1 with NMDAR and 
      unknown antibodies, were identified during retrospective assessment of 34 HSE 
      patients; the frequency of autoantibodies increased over time (serum, p=0.004; 
      cerebrospinal fluid, p=0.04). The 3 retrospectively identified NMDAR 
      antibody-positive patients also had evidence of relapsing post-HSE. Overall, 
      these findings indicate that HSE triggers NMDAR antibodies and potentially other 
      brain autoimmunity.
CI  - (c) 2014 American Neurological Association.
FAU - Armangue, Thais
AU  - Armangue T
AD  - August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Neurology Service, 
      Hospital Clinic, University of Barcelona, Barcelona, Spain; Department of 
      Pediatric Neurology, Materno-Infantil Vall d'Hebron Hospital, Autonomous 
      University of Barcelona, Barcelona, Spain.
FAU - Leypoldt, Frank
AU  - Leypoldt F
FAU - Malaga, Ignacio
AU  - Malaga I
FAU - Raspall-Chaure, Miquel
AU  - Raspall-Chaure M
FAU - Marti, Itxaso
AU  - Marti I
FAU - Nichter, Charles
AU  - Nichter C
FAU - Pugh, John
AU  - Pugh J
FAU - Vicente-Rasoamalala, Monica
AU  - Vicente-Rasoamalala M
FAU - Lafuente-Hidalgo, Miguel
AU  - Lafuente-Hidalgo M
FAU - Macaya, Alfons
AU  - Macaya A
FAU - Ke, Michael
AU  - Ke M
FAU - Titulaer, Maarten J
AU  - Titulaer MJ
FAU - Hoftberger, Romana
AU  - Hoftberger R
FAU - Sheriff, Heather
AU  - Sheriff H
FAU - Glaser, Carol
AU  - Glaser C
FAU - Dalmau, Josep
AU  - Dalmau J
LA  - eng
GR  - R01 NS077851/NS/NINDS NIH HHS/United States
GR  - R01NS077851/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140225
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Autoimmunity/*physiology
MH  - Brain/*physiopathology
MH  - Child, Preschool
MH  - Encephalitis, Herpes Simplex/blood/cerebrospinal fluid/*pathology
MH  - Female
MH  - HEK293 Cells
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prospective Studies
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/blood
MH  - Retrospective Studies
MH  - Transfection
MH  - Young Adult
PMC - PMC3961499
MID - NIHMS548631
EDAT- 2013/12/10 06:00
MHDA- 2014/05/06 06:00
PMCR- 2015/02/25
CRDT- 2013/12/10 06:00
PHST- 2013/08/27 00:00 [received]
PHST- 2013/11/26 00:00 [revised]
PHST- 2013/11/29 00:00 [accepted]
PHST- 2013/12/10 06:00 [entrez]
PHST- 2013/12/10 06:00 [pubmed]
PHST- 2014/05/06 06:00 [medline]
PHST- 2015/02/25 00:00 [pmc-release]
AID - 10.1002/ana.24083 [doi]
PST - ppublish
SO  - Ann Neurol. 2014 Feb;75(2):317-23. doi: 10.1002/ana.24083. Epub 2014 Feb 25.