PMID- 24319012
OWN - NLM
STAT- MEDLINE
DCOM- 20141107
LR  - 20220331
IS  - 1460-2385 (Electronic)
IS  - 0931-0509 (Linking)
VI  - 29
IP  - 6
DP  - 2014 Jun
TI  - A novel autoantibody against moesin in the serum of patients with 
      MPO-ANCA-associated vasculitis.
PG  - 1168-77
LID - 10.1093/ndt/gft469 [doi]
AB  - BACKGROUND: Antineutrophil cytoplasmic autoantibody (ANCA) directed against 
      myeloperoxidase (MPO), a diagnostic criterion in MPO-ANCA-associated vasculitis 
      (MPO-AAV), does not always correlate with disease activity. Here, we detected 
      autoantibodies against moesin, which was located on the surface of stimulated 
      endothelial cells, in the serum of patients. METHODS: The anti-moesin 
      autoantibody titer was evaluated by ELISA. Seventeen kinds of 
      cytokines/chemokines were measured by a Bio-Plex system. RESULTS: Serum 
      creatinine in the anti-moesin autoantibody-positive group was higher than that in 
      the negative group. Additionally, interferon (IFN)-gamma, macrophage chemotactic 
      peptide-1 (MCP-1), interleukin (IL)-2, IL-7, IL-12p70, IL-13, 
      granulocyte/macrophage colony-stimulating factor (GM-CSF) and granulocyte 
      colony-stimulating factor were significantly higher in the positive group. 
      Furthermore, IL-7 and IL-12p70 levels correlated with the anti-moesin 
      autoantibody titer. Based on these findings and the binding of anti-moesin IgG to 
      neutrophils and monocytes, we detected the secretion of cytokines/chemokines such 
      as IFN-gamma, MCP-1 and GM-CSF from these cells. CONCLUSIONS: The anti-moesin 
      autoantibody existed in the serum of patients with MPO-AAV and was associated 
      with the production of inflammatory cytokines/chemokines targeting neutrophils 
      with a cytoplasmic profile, which suggests that the anti-moesin autoantibody has 
      the possibility to be a novel autoantibody developing vasculitis via neutrophil 
      and endothelial cell activation.
CI  - (c) The Author 2013. Published by Oxford University Press on behalf of ERA-EDTA. 
      All rights reserved.
FAU - Suzuki, Koya
AU  - Suzuki K
AD  - Inflammation Program, Chiba University, Graduate School of Medicine, Chiba City, 
      Japan Graduate School of Life and Environmental Science, Tsukuba University, 
      Tsukuba, Ibaragi, Japan Laboratory of Biological Science, Graduate School of 
      Frontier Biosciences, Graduate School of Medicine, Osaka University, Suita, 
      Osaka, Japan.
FAU - Nagao, Tomokazu
AU  - Nagao T
AD  - Inflammation Program, Chiba University, Graduate School of Medicine, Chiba City, 
      Japan.
FAU - Itabashi, Mitsuyo
AU  - Itabashi M
AD  - Department of Internal Medicine, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Hamano, Yoshitomo
AU  - Hamano Y
AD  - Department of Internal Medicine, Jichi University, School of Medicine, 
      Shimotsuke, Tochigi, Japan.
FAU - Sugamata, Ryuichi
AU  - Sugamata R
AD  - Inflammation Program, Chiba University, Graduate School of Medicine, Chiba City, 
      Japan.
FAU - Yamazaki, Yuji
AU  - Yamazaki Y
AD  - Laboratory of Biological Science, Graduate School of Frontier Biosciences, 
      Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
FAU - Yumura, Wako
AU  - Yumura W
AD  - Department of Internal Medicine, Jichi University, School of Medicine, 
      Shimotsuke, Tochigi, Japan.
FAU - Tsukita, Sachiko
AU  - Tsukita S
AD  - Laboratory of Biological Science, Graduate School of Frontier Biosciences, 
      Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
FAU - Wang, Pi-Chao
AU  - Wang PC
AD  - Graduate School of Life and Environmental Science, Tsukuba University, Tsukuba, 
      Ibaragi, Japan.
FAU - Nakayama, Toshinori
AU  - Nakayama T
AD  - Department of Immunology, Chiba University, Graduate School of Medicine, Chiba 
      City, Japan.
FAU - Suzuki, Kazuo
AU  - Suzuki K
AD  - Inflammation Program, Chiba University, Graduate School of Medicine, Chiba City, 
      Japan Asia International Institute of Infectious Disease Control, Department of 
      Health Protection, Graduate School of Medicine, Teikyo University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131205
PL  - England
TA  - Nephrol Dial Transplant
JT  - Nephrology, dialysis, transplantation : official publication of the European 
      Dialysis and Transplant Association - European Renal Association
JID - 8706402
RN  - 0 (Autoantibodies)
RN  - 0 (Chemokines)
RN  - 0 (Interleukins)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Microfilament Proteins)
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
RN  - 144131-77-1 (moesin)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
CIN - Nephrol Dial Transplant. 2014 Jun;29(6):1105-7. PMID: 24459139
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/*immunology
MH  - Autoantibodies/*blood
MH  - Chemokines/metabolism
MH  - Endothelium, Vascular/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Granulocyte Colony-Stimulating Factor/blood
MH  - Humans
MH  - Interleukins/immunology
MH  - Macrophage Inflammatory Proteins/blood
MH  - Male
MH  - Microfilament Proteins/*immunology
MH  - Middle Aged
MH  - Peroxidase/*immunology
OTO - NOTNLM
OT  - autoantibodies
OT  - glomerulonephritis
OT  - moesin
OT  - myeloperoxidase
OT  - neutrophil
EDAT- 2013/12/10 06:00
MHDA- 2014/11/08 06:00
CRDT- 2013/12/10 06:00
PHST- 2013/12/10 06:00 [entrez]
PHST- 2013/12/10 06:00 [pubmed]
PHST- 2014/11/08 06:00 [medline]
AID - gft469 [pii]
AID - 10.1093/ndt/gft469 [doi]
PST - ppublish
SO  - Nephrol Dial Transplant. 2014 Jun;29(6):1168-77. doi: 10.1093/ndt/gft469. Epub 
      2013 Dec 5.