PMID- 24319335
OWN - NLM
STAT- MEDLINE
DCOM- 20140721
LR  - 20211021
IS  - 1090-0535 (Electronic)
IS  - 1090-0535 (Linking)
VI  - 19
DP  - 2013
TI  - Aqueous cytokines as predictors of macular edema in non-diabetic patients 
      following uncomplicated phacoemulsification cataract surgery.
PG  - 2418-25
AB  - PURPOSE: To ascertain whether cytokines in the aqueous humor can predict macular 
      edema (ME) in non-diabetic patients following uncomplicated phacoemulsification 
      cataract surgery. METHODS: Undiluted aqueous humor samples were obtained from 288 
      consecutive non-diabetic patients (288 eyes; 132 men and 156 women) who underwent 
      cataract surgery. Macular edema was defined as an increase in the foveal center 
      point thickness (FCPT) more than 30% from the preoperative baseline using optical 
      coherence tomography 4 weeks after cataract surgery. The concentrations of 27 
      cytokines were measured in aqueous humor samples using the multiplex bead 
      immunoassay. RESULTS: No major intraoperative complications occurred. The 
      incidence of ME was 8.13% (23 patients) 4 weeks after cataract surgery. Compared 
      to the ME (-) patients, the concentrations of interleukin-1beta (IL-1beta; p=0.016), 
      IL-6 (p=0.013), monocyte chemotactic protein-1 (MCP-1; p=0.030), and vascular 
      endothelial growth factor (VEGF; p=0.033) in the ME (+) patients were 
      significantly higher. In addition, the aqueous humor levels of IL-1beta (r=0.376), 
      IL-6 (r=0.418), MCP-1 (r=0.348), and VEGF (r=0.375) positively correlated with 
      the postoperative FCPT. However, the aqueous humor levels of IL-10 (p=0.017) were 
      significantly lower in patients with ME and were negatively correlated with the 
      postoperative FCPT (r=-0.424). CONCLUSIONS: IL-1beta, IL-6, MCP-1, VEGF, and IL-10 
      may be potential predictors of postoperative macular thickness in non-diabetic 
      patients following uncomplicated phacoemulsification cataract surgery.
FAU - Chu, Liqun
AU  - Chu L
AD  - Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical 
      University, Beijing, People's Republic of China.
FAU - Wang, Bingsong
AU  - Wang B
FAU - Xu, Bing
AU  - Xu B
FAU - Dong, Ning
AU  - Dong N
LA  - eng
PT  - Journal Article
DEP - 20131124
PL  - United States
TA  - Mol Vis
JT  - Molecular vision
JID - 9605351
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aqueous Humor/*immunology
MH  - Biomarkers/metabolism
MH  - Cataract/immunology/pathology
MH  - *Cataract Extraction
MH  - Cross-Sectional Studies
MH  - Cytokines/genetics/*immunology
MH  - Female
MH  - Fovea Centralis/immunology/pathology
MH  - Gene Expression
MH  - Humans
MH  - Immunoassay
MH  - Macular Edema/*diagnosis/*immunology/pathology
MH  - Male
MH  - Middle Aged
MH  - *Phacoemulsification
MH  - Prognosis
MH  - Tomography, Optical Coherence
PMC - PMC3850971
EDAT- 2013/12/10 06:00
MHDA- 2014/07/22 06:00
PMCR- 2013/01/01
CRDT- 2013/12/10 06:00
PHST- 2013/08/03 00:00 [received]
PHST- 2013/11/22 00:00 [accepted]
PHST- 2013/12/10 06:00 [entrez]
PHST- 2013/12/10 06:00 [pubmed]
PHST- 2014/07/22 06:00 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - 241 [pii]
PST - epublish
SO  - Mol Vis. 2013 Nov 24;19:2418-25. eCollection 2013.