PMID- 24320179
OWN - NLM
STAT- MEDLINE
DCOM- 20140218
LR  - 20131210
IS  - 0289-0003 (Print)
IS  - 0289-0003 (Linking)
VI  - 30
IP  - 12
DP  - 2013 Dec
TI  - Sex differences in stress reactivity of hippocampal BDNF in mice are associated 
      with the female preponderance of decreased locomotor activity in response to 
      restraint stress.
PG  - 1019-24
LID - 10.2108/zsj.30.1019 [doi]
AB  - The incidence and prevalence of depression is higher in women than in men, but 
      the cause of this sex discrepancy remains unknown. Brain-derived neurotrophic 
      factor (BDNF) is a key protein for maintaining neuronal integrity. The purpose of 
      this study was to investigate the female preponderance in behavioral responsivity 
      to restraint stress focusing on the stress reactivity of BDNF in the hippocampus. 
      Male and female ICR mice were exposed to a 3-h session of restraint stress. 
      Plasma corticosterone was measured by high-performance liquid chromatography. 
      BDNF mRNA expression in the whole hippocampus was measured by quantitative 
      real-time reverse transcription-polymerase chain reaction. Wheel-running activity 
      was monitored during the dark period. In response to restraint stress, the 
      increase in levels of serum corticosterone was higher in female than in male 
      mice. Restraint stress resulted in decreased voluntary wheel-running behavior 
      that was greater in female than male animals. In addition to these sex 
      differences in stress reactivity, we found a significant sex difference in BDNF 
      levels in the hippocampus of restraint-stressed mice; total BDNF levels 
      significantly decreased in female mice, but not in male mice in response to the 
      stress. Furthermore, BDNF exon I and IV mRNA expression also showed the same 
      tendency. These data indicate that the reduction in levels of voluntary 
      wheel-running activity in response to stress can be significantly influenced by 
      sex. Moreover, our findings suggest a link between the sex differences in this 
      behavioral response to stress and differential stress reactivity in the 
      production of BDNF in the hippocampus.
FAU - Yamaura, Katsunori
AU  - Yamaura K
AD  - 1 Department of Geriatric Pharmacology and Therapeutics, Graduate School of 
      Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 
      260-8675, Japan.
FAU - Bi, Yuanyuan
AU  - Bi Y
FAU - Ishiwatari, Makiko
AU  - Ishiwatari M
FAU - Oishi, Nobuo
AU  - Oishi N
FAU - Fukata, Hideki
AU  - Fukata H
FAU - Ueno, Koichi
AU  - Ueno K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Zoolog Sci
JT  - Zoological science
JID - 8702287
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Corticosterone/blood
MH  - Eating
MH  - Female
MH  - Gene Expression Regulation/physiology
MH  - Hippocampus
MH  - Male
MH  - Membrane Glycoproteins/genetics/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - *Motor Activity
MH  - Protein-Tyrosine Kinases/genetics/metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Restraint, Physical/*physiology
MH  - Sex Factors
MH  - *Stress, Physiological
EDAT- 2013/12/11 06:00
MHDA- 2014/02/19 06:00
CRDT- 2013/12/11 06:00
PHST- 2013/12/11 06:00 [entrez]
PHST- 2013/12/11 06:00 [pubmed]
PHST- 2014/02/19 06:00 [medline]
AID - 10.2108/zsj.30.1019 [doi]
PST - ppublish
SO  - Zoolog Sci. 2013 Dec;30(12):1019-24. doi: 10.2108/zsj.30.1019.