PMID- 24323125
OWN - NLM
STAT- MEDLINE
DCOM- 20140910
LR  - 20140212
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 25
IP  - 4
DP  - 2014 Mar 5
TI  - Effect of interstimulus interval and age on cortical auditory evoked potentials 
      in 10-22-week-old infants.
PG  - 248-54
LID - 10.1097/WNR.0000000000000078 [doi]
AB  - This study compares cortical auditory evoked potentials (CAEPs) at different 
      interstimulus intervals (ISIs) in infants to determine the impact of stimulus 
      rate on wave morphology. Infant CAEPs are dominated by a positive peak P1. We 
      hypothesized that infant CAEPs would be more adult-like at longer ISI with P1, 
      followed by negativity (labelled N450). Participants were 10 typically developing 
      infants aged 10-13 weeks (N=4) and 20-22 weeks (N=6). CAEPs were measured in one 
      recording session for /da/ in quiet at 55 dB SPL for ISIs of 910, 1820, 3640 and 
      4550 ms in a randomized order. Recordings were complete at each ISI for 7-10 
      infants. Seven infants who completed all testing in quiet were also tested in 
      continuous white noise (+5 dB signal-to-noise ratio) for the shortest ISI. P1 was 
      observable in all infants; N450 was only present in the older infants. There 
      appeared to be no ISI effect for younger or older infants, which is not 
      consistent with ISI findings for adults and older children. The presence of N450 
      in the older infants only suggests that cortical maturational differences are 
      evident in speech-evoked CAEPs in young infants. There were minimal effects of 
      noise on P1 latency and amplitude. Results suggest different effects of ISI for 
      very young infants than those observed in older infants and children. CAEPs are 
      being used to measure hearing aid effectiveness in young infants and hence it is 
      imperative that the effects of factors such as ISI are better understood.
FAU - Sharma, Mridula
AU  - Sharma M
AD  - aAudiology Section, Macquarie University, Australia bHearing Co-operative 
      Research Centre, Australia cThe Hearing and Balance Centre, St Vincent Hospital, 
      Darlinghurst, New South Wales, Australia dNational Hearing Care, Australia 
      eDepartment of Discipline of Speech Science, The University of Auckland, 
      Auckland, New Zealand.
FAU - Johnson, Patrice K H
AU  - Johnson PK
FAU - Purdy, Suzanne C
AU  - Purdy SC
FAU - Norman, Farah
AU  - Norman F
LA  - eng
PT  - Journal Article
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
SB  - IM
MH  - Acoustic Stimulation
MH  - Analysis of Variance
MH  - *Auditory Perception
MH  - Cerebral Cortex/growth & development/*physiology
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Noise
MH  - Speech Acoustics
MH  - Speech Perception
MH  - Time Factors
EDAT- 2013/12/11 06:00
MHDA- 2014/09/11 06:00
CRDT- 2013/12/11 06:00
PHST- 2013/12/11 06:00 [entrez]
PHST- 2013/12/11 06:00 [pubmed]
PHST- 2014/09/11 06:00 [medline]
AID - 10.1097/WNR.0000000000000078 [doi]
PST - ppublish
SO  - Neuroreport. 2014 Mar 5;25(4):248-54. doi: 10.1097/WNR.0000000000000078.