PMID- 24323371
OWN - NLM
STAT- MEDLINE
DCOM- 20141118
LR  - 20250529
IS  - 1574-4647 (Electronic)
IS  - 0161-9152 (Print)
IS  - 0161-9152 (Linking)
VI  - 36
IP  - 2
DP  - 2014 Apr
TI  - Health status and 6 years survival of 552 90+ Italian sib-ships recruited within 
      the EU Project GEHA (GEnetics of Healthy Ageing).
PG  - 949-66
LID - 10.1007/s11357-013-9604-1 [doi]
AB  - In a scenario of increasing life expectancy worldwide, it is mandatory to 
      identify the characteristics of a healthy aging phenotype, including survival 
      predictors, and to disentangle those related to environment/lifestyle versus 
      those related to familiarity/genetics. To this aim we comprehensively 
      characterised a cohort of 1,160 Italian subjects of 90 years and over (90+, mean 
      age 93 years; age range 90-106 years) followed for 6 years survival, belonging to 
      552 sib-ships (familiar longevity) recruited (2005-2008) within the EU-funded 
      GEHA project in three Italian geographic areas (Northern, Central and Southern 
      Italy) different for urban/rural and socio-economical characteristics. On the 
      whole, the following factors emerged as significant predictors of survival after 
      90 years of age: absence of cognitive impairment and physical disability, high 
      hand grip strength scores and body mass index (BMI) values, "excellent/good" 
      self-reported health, high haemoglobin and total cholesterol levels and low 
      creatinine levels. These parameters, excluding BMI values, were also 
      significantly associated within sib-ships, suggesting a strong familial/genetic 
      component. Geographical micro-heterogeneity of survival predictors emerged, such 
      as functional and physical status being more important in Southern than in 
      Central and Northern Italy. In conclusion, we identified modifiable survival 
      predictors related to specific domains, whose role and importance vary according 
      to the geographic area considered and which can help in interpreting the genetic 
      results obtained by the GEHA project, whose major aim is the comprehensive 
      evaluation of phenotypic and genetic data.
FAU - Cevenini, E
AU  - Cevenini E
AD  - C.I.G.-Interdepartmental Centre "L. Galvani", University of Bologna, Piazza di 
      Porta San Donato 1, 40126, Bologna, Italy.
FAU - Cotichini, R
AU  - Cotichini R
FAU - Stazi, M A
AU  - Stazi MA
FAU - Toccaceli, V
AU  - Toccaceli V
FAU - Palmas, M G
AU  - Palmas MG
FAU - Capri, M
AU  - Capri M
FAU - De Rango, F
AU  - De Rango F
FAU - Dato, S
AU  - Dato S
FAU - Passarino, G
AU  - Passarino G
FAU - Jeune, B
AU  - Jeune B
FAU - Franceschi, C
AU  - Franceschi C
CN  - GEHA Project Consortium
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - BB/C008200/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20131210
PL  - Netherlands
TA  - Age (Dordr)
JT  - Age (Dordrecht, Netherlands)
JID - 101250497
SB  - IM
MH  - *Activities of Daily Living
MH  - Aged, 80 and over
MH  - Aging/*genetics
MH  - Databases, Factual
MH  - Europe/epidemiology
MH  - Female
MH  - Follow-Up Studies
MH  - *Health Status
MH  - Humans
MH  - Italy/epidemiology
MH  - Longevity/*genetics
MH  - Male
MH  - Phenotype
MH  - Retrospective Studies
MH  - Survival Rate/trends
PMC - PMC4039258
FIR - Bezrukov, Vladyslav
IR  - Bezrukov V
FIR - Blanche, Helene
IR  - Blanche H
FIR - Bolund, Lars
IR  - Bolund L
FIR - Christensen, Kaare
IR  - Christensen K
FIR - Deiana, Luca
IR  - Deiana L
FIR - Gonos, Efsthatios
IR  - Gonos E
FIR - Hervonen, Antti
IR  - Hervonen A
FIR - Kirkwood, Tom B L
IR  - Kirkwood TB
FIR - Kristensen, Peter
IR  - Kristensen P
FIR - Leon, Alberta
IR  - Leon A
FIR - Pelicci, Pier Giuseppe
IR  - Pelicci PG
FIR - Perola, Markus
IR  - Perola M
FIR - Poulain, Michel
IR  - Poulain M
FIR - Rea, Irene M
IR  - Rea IM
FIR - Remacle, Jose
IR  - Remacle J
FIR - Robine, Jean Marie
IR  - Robine JM
FIR - Schreiber, Stefan
IR  - Schreiber S
FIR - Sikora, Ewa
IR  - Sikora E
FIR - Slagboom, P Eline
IR  - Slagboom P
FIR - Spazzafumo, Liana
IR  - Spazzafumo L
FIR - Toussaint, Olivier
IR  - Toussaint O
FIR - Vaupel, James W
IR  - Vaupel JW
EDAT- 2013/12/11 06:00
MHDA- 2014/11/19 06:00
PMCR- 2015/04/01
CRDT- 2013/12/11 06:00
PHST- 2013/05/06 00:00 [received]
PHST- 2013/11/26 00:00 [accepted]
PHST- 2013/12/11 06:00 [entrez]
PHST- 2013/12/11 06:00 [pubmed]
PHST- 2014/11/19 06:00 [medline]
PHST- 2015/04/01 00:00 [pmc-release]
AID - 9604 [pii]
AID - 10.1007/s11357-013-9604-1 [doi]
PST - ppublish
SO  - Age (Dordr). 2014 Apr;36(2):949-66. doi: 10.1007/s11357-013-9604-1. Epub 2013 Dec 
      10.